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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gng13tm1Liqh
targeted mutation 1, Liquan Huang
MGI:5517361
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gng13tm1Liqh/Gng13tm1Liqh
Omptm4(cre)Mom/Omp+ 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:5517417


Genotype
MGI:5517417
cn1
Allelic
Composition		 Gng13tm1Liqh/Gng13tm1Liqh
Omptm4(cre)Mom/Omp+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gng13tm1Liqh mutation (0 available); any Gng13 mutation (8 available)
Omptm4(cre)Mom mutation (2 available); any Omp mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:197147 )
• although mice are grossly normal, those born into litters of 7 or more display compromised survival

taste/olfaction
abnormal olfactory system morphology ( J:197147 )
• olfactory glomerular structures and axon bundles are somewhat altered
abnormal olfactory sensory neuron physiology ( J:197147 )
• 15 odorants tested including the pheromones 2-heptanone, DMP, and TMT
• "electro-olfactogram" response to all odorants is significantly diminished
• TEA response becomes positive rather than the typical negative
impaired olfaction ( J:197147 )
• mice deprived of food for 1 day take 518 seconds to find a buried food pellet scented with peanut butter whereas controls take 26-27 seconds
• all mice find the pellet rapidly when placed on the surface of the bedding

nervous system
abnormal olfactory sensory neuron physiology ( J:197147 )
• 15 odorants tested including the pheromones 2-heptanone, DMP, and TMT
• "electro-olfactogram" response to all odorants is significantly diminished
• TEA response becomes positive rather than the typical negative

respiratory system
abnormal olfactory sensory neuron physiology ( J:197147 )
• 15 odorants tested including the pheromones 2-heptanone, DMP, and TMT
• "electro-olfactogram" response to all odorants is significantly diminished
• TEA response becomes positive rather than the typical negative




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory