Analysis Tools|
Allele Symbol Allele Name Allele ID |
Nr2c2tm1Bbm targeted mutation 1, Allan Basbaum MGI:5517362 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal pain and itch behaviors
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| N |
• mice exhibit normal spinal cord organization
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal performance in the Morris Water Maze and the open field test
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• mice exhibit a small increase in the time spent in the open arms of a zero maze compared with wild-type mice
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• mice exhibit impaired performance on a ledge test compared with wild-type mice
• however, mice exhibit normal performance on a rotarod unlike Nr2c2tm1Chc homozygotes
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• following nerve-injury induced persistent pain, mice exhibit less mechanical hyperalegsia with greater sensitized threshold compared with wild-type mice
• in a model of nerve injury-induced neuropathic pain or in the spared nerve injury model of neuropathic pain, mice exhibit a decreased magnitude of thermal hyperalgesia with absent mechanical hyperalgesia compared with wild-type mice
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• in response to capsaicin or formalin
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• mice exhibit increased reflex withdrawal thresholds in the von Frey test of mechanical pain compared with wild-type mice
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• mice exhibit high response latencies in a hot plate test compared with wild-type mice
• however, mice exhibit normal response in the Hargreaves and tail immersion reflex withdrawal tests
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• alteration of primary afferent terminations in the dorsal horn
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• neuronal loss in the superficial dorsal horn
• selective loss of excitatory neurons in the superficial dorsal horn
• however, projection neurons are spared
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• mice exhibit decreased noxious stimulus-induced responsiveness of presumptive dorsal horn projection neurons compared with wild-type mice
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• puritogen-induced itch is absent
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal pain and itch behaviors
|
| N |
• mice exhibit normal spinal cord organization
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• puritogen-induced itch is absent
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• in response to formalin
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• mice exhibit increased reflex withdrawal thresholds in the von Frey test of mechanical pain compared with wild-type mice
|
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• mice exhibit high response latencies in a hot plate test compared with wild-type mice
• however, mice exhibit normal response in the Hargreaves and tail immersion reflex withdrawal tests
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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