Phenotypes associated with this allele

• Allele Symbol: Tg(CTSG-ZBTB16/RARA)#Sjch
• Allele Name: transgene insertion, Sai-Juan Chen
• Allele ID: MGI:5517398
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(CTSG-RARA/ZBTB16)#Sjch/0 Tg(CTSG-ZBTB16/RARA)#Sjch/0	Not Specified	MGI:5517439
tg2	Tg(CTSG-ZBTB16/RARA)#Sjch/0	involves: C57BL/6	MGI:5517402

Genotype
MGI:5517439

cx1

• Allelic Composition: Tg(CTSG-RARA/ZBTB16)#Sjch/0; Tg(CTSG-ZBTB16/RARA)#Sjch/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

impaired hematopoiesis ( J:194312 )

• impairment of normal hematopoiesis

neoplasm

increased acute promyelocytic leukemia incidence ( J:194312 )

• mutants develop myeloid leukemia resembling human t(11;17) acute promyelocytic leukemia, showing an accumulation of immature myeloblastic cells in hematopoietic tissues and infiltration of nonhematopoietic organs, including the liver, lung, gastrointestinal tract, and kidney

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute promyelocytic leukemia		DOID:0060318	OMIM:612376	J:194312

Genotype
MGI:5517402

tg2

• Allelic Composition: Tg(CTSG-ZBTB16/RARA)#Sjch/0
• Genetic Background: involves: C57BL/6

neoplasm

increased leukemia incidence ( J:55196 )

• 6 of 51 founders develop leukemia, usually with short latent periods of 31-85 days after birth

increased chronic myelocytic leukemia incidence ( J:55196 )

• develop chronic myeloid leukemia-like phenotypes within 3 months of life

• mutants with leukemia show an increased percentage of mature myeloid cells and myeloid/lymphoid ratio in the peripheral blood and bone marrow resembling chronic myeloid leukemia

growth/size/body

decreased body weight ( J:55196 )

• mutants with leukemia have low body weight

enlarged spleen ( J:55196 )

• mutants with leukemia exhibit splenomegaly

hematopoietic system

abnormal myelopoiesis ( J:55196 )

• about 20% increase in promyelocytes

• extreme expansion of myeloid cells at varying stages of maturation

myeloid hyperplasia ( J:55196 )

• extreme expansion of myeloid cells at varying stages of maturation

increased leukocyte cell number ( J:55196 )

abnormal spleen morphology ( J:55196 )

• follicular architecture is damaged

enlarged spleen ( J:55196 )

• mutants with leukemia exhibit splenomegaly

abnormal spleen red pulp morphology ( J:55196 )

• red pulp is infiltrated by myeloid cells, mainly myelocytes, metamyelocytes, and segmented forms

abnormal bone marrow cell physiology ( J:55196 )

• all-trans-retinoic acid treatment does not induce bone marrow cells to differentiate as in controls

immune system

abnormal myelopoiesis ( J:55196 )

• about 20% increase in promyelocytes

• extreme expansion of myeloid cells at varying stages of maturation

myeloid hyperplasia ( J:55196 )

• extreme expansion of myeloid cells at varying stages of maturation

increased leukocyte cell number ( J:55196 )

abnormal spleen morphology ( J:55196 )

• follicular architecture is damaged

enlarged spleen ( J:55196 )

• mutants with leukemia exhibit splenomegaly

abnormal spleen red pulp morphology ( J:55196 )

• red pulp is infiltrated by myeloid cells, mainly myelocytes, metamyelocytes, and segmented forms

liver/biliary system

abnormal liver morphology ( J:55196 )

• focal infiltration of liver with myeloid precursors, however gross structure of the liver is unaffected

skeleton

abnormal bone marrow morphology ( J:55196 )

• disruption of bone marrow trabeculae