All Phenotypes Scs MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Scs
semi-dominant compacted skeleton
MGI:5517547

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scs/Scs	involves: C57BL/6J * C3H/H	MGI:5519886
ht2	Scs/+	C3H/He-Scs/GrsrJ	MGI:5646117
ht3	Scs/+	(C3H/He-Scs/GrsrJ x C57BL/6J)F1	MGI:5519899
ht4	Scs/+	(C3H/He-Scs/GrsrJ x CAST/EiJ)F1	MGI:5646119

Allelic Composition	Scs/Scs
Genetic Background	involves: C57BL/6J * C3H/H

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scs mutation (1 available); any Scs mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Short tail and compact body in Scs/+ (center) and Scs/Scs (right) mice compared to wild-type (left)

skeleton

abnormal axial skeleton morphology ( J:202091 )

abnormal rib morphology ( J:202091 )

• ribs are often bifurcated or fused

rib bifurcation ( J:202091 )

rib fusion ( J:202091 )

abnormal vertebral column morphology ( J:202091 )

• compressed, shortened, sometimes crooked or kinked spine and tail

abnormal intervertebral disk morphology ( J:202091 )

• intervertebral discs are sometimes missing or herniated

abnormal vertebrae morphology ( J:202091 )

• cervical, thoracic, lumbar and sacral vertebrae can be compressed, misshapen, and irregularly aligned and misaligned vertebrae are often fused resulting in a crooked spine or tail kink

vertebral compression ( J:202091 )

vertebral fusion ( J:202091 )

short vertebral column ( J:202091 )

• the vertebral defects result in a compressed, shortened body length

abnormal skeleton development ( J:202091 )

limbs/digits/tail

short tail ( J:202091 )

• homozygotes have a very short tail, approximately a half inch or less, which can be stumpy or kinked

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:202091 )

N	• normal hearing by ABR of one homozygote at 39 days of age, one homozygote at 81 days of age, and one homozygote at 4 months of age

Allelic Composition	Scs/+
Genetic Background	C3H/He-Scs/GrsrJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scs mutation (1 available); any Scs mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal axial skeleton morphology ( J:202091 )

• shortened, compacted body due to abnormal axial skeleton development

abnormal skeleton development ( J:202091 )

limbs/digits/tail

short tail ( J:202091 )

• somewhat stumpy and sometimes kinked tail approximately three quarters of an inch in length

Allelic Composition	Scs/+
Genetic Background	(C3H/He-Scs/GrsrJ x C57BL/6J)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scs mutation (1 available); any Scs mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Abnormal axial skeleton morphology and short tail in Scs/+ mouse

skeleton

abnormal axial skeleton morphology ( J:202091 )

abnormal rib morphology ( J:202091 )

• fused or bifurcated ribs can be found

rib bifurcation ( J:202091 )

rib fusion ( J:202091 )

abnormal vertebral column morphology ( J:202091 )

• compressed, shortened, sometimes crooked or kinked spine and tail

abnormal intervertebral disk morphology ( J:202091 )

• intervertebral discs are sometimes missing or herniated

absent intervertebral disk ( J:202091 )

prolapsed intervertebral disk ( J:202091 )

abnormal vertebrae morphology ( J:202091 )

• cervical, thoracic, lumbar and sacral vertebrae can be compressed, misshapen, and irregularly aligned and misaligned vertebrae can be fused resulting in a crooked spine or tail kink

vertebral compression ( J:202091 )

vertebral fusion ( J:202091 )

short vertebral column ( J:202091 )

• the vertebral defects result in a compressed, shortened body length

abnormal skeleton development ( J:202091 )

limbs/digits/tail

short tail ( J:202091 )

Allelic Composition	Scs/+
Genetic Background	(C3H/He-Scs/GrsrJ x CAST/EiJ)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scs mutation (1 available); any Scs mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

short tail ( J:202091 )

• somewhat stumpy and sometimes kinked tail approximately three quarters of an inch in length

skeleton

abnormal axial skeleton morphology ( J:202091 )

• shortened, compacted body due to abnormal axial skeleton development

abnormal skeleton development ( J:202091 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24