Phenotypes associated with this allele

• Allele Symbol: Scs
• Allele Name: semi-dominant compacted skeleton
• Allele ID: MGI:5517547
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scs/Scs	involves: C57BL/6J * C3H/H	MGI:5519886
ht2	Scs/+	C3H/He-Scs/GrsrJ	MGI:5646117
ht3	Scs/+	(C3H/He-Scs/GrsrJ x C57BL/6J)F1	MGI:5519899
ht4	Scs/+	(C3H/He-Scs/GrsrJ x CAST/EiJ)F1	MGI:5646119

Genotype
MGI:5519886

hm1

• Allelic Composition: Scs/Scs
• Genetic Background: involves: C57BL/6J * C3H/H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Short tail and compact body in Scs/+ (center) and Scs/Scs (right) mice compared to wild-type (left)

skeleton

abnormal axial skeleton morphology ( J:202091 )

abnormal rib morphology ( J:202091 )

• ribs are often bifurcated or fused

rib bifurcation ( J:202091 )

rib fusion ( J:202091 )

abnormal vertebral column morphology ( J:202091 )

• compressed, shortened, sometimes crooked or kinked spine and tail

abnormal intervertebral disk morphology ( J:202091 )

• intervertebral discs are sometimes missing or herniated

abnormal vertebrae morphology ( J:202091 )

• cervical, thoracic, lumbar and sacral vertebrae can be compressed, misshapen, and irregularly aligned and misaligned vertebrae are often fused resulting in a crooked spine or tail kink

vertebral compression ( J:202091 )

vertebral fusion ( J:202091 )

short vertebral column ( J:202091 )

• the vertebral defects result in a compressed, shortened body length

abnormal skeleton development ( J:202091 )

limbs/digits/tail

short tail ( J:202091 )

• homozygotes have a very short tail, approximately a half inch or less, which can be stumpy or kinked

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:202091 )

N • normal hearing by ABR of one homozygote at 39 days of age, one homozygote at 81 days of age, and one homozygote at 4 months of age

Genotype
MGI:5646117

ht2

• Allelic Composition: Scs/+
• Genetic Background: C3H/He-Scs/GrsrJ

skeleton

abnormal axial skeleton morphology ( J:202091 )

• shortened, compacted body due to abnormal axial skeleton development

abnormal skeleton development ( J:202091 )

limbs/digits/tail

short tail ( J:202091 )

• somewhat stumpy and sometimes kinked tail approximately three quarters of an inch in length

Genotype
MGI:5519899

ht3

• Allelic Composition: Scs/+
• Genetic Background: (C3H/He-Scs/GrsrJ x C57BL/6J)F1

Abnormal axial skeleton morphology and short tail in Scs/+ mouse

skeleton

abnormal axial skeleton morphology ( J:202091 )

abnormal rib morphology ( J:202091 )

• fused or bifurcated ribs can be found

rib bifurcation ( J:202091 )

rib fusion ( J:202091 )

abnormal vertebral column morphology ( J:202091 )

• compressed, shortened, sometimes crooked or kinked spine and tail

abnormal intervertebral disk morphology ( J:202091 )

• intervertebral discs are sometimes missing or herniated

absent intervertebral disk ( J:202091 )

prolapsed intervertebral disk ( J:202091 )

abnormal vertebrae morphology ( J:202091 )

• cervical, thoracic, lumbar and sacral vertebrae can be compressed, misshapen, and irregularly aligned and misaligned vertebrae can be fused resulting in a crooked spine or tail kink

vertebral compression ( J:202091 )

vertebral fusion ( J:202091 )

short vertebral column ( J:202091 )

• the vertebral defects result in a compressed, shortened body length

abnormal skeleton development ( J:202091 )

limbs/digits/tail

short tail ( J:202091 )

Genotype
MGI:5646119

ht4

• Allelic Composition: Scs/+
• Genetic Background: (C3H/He-Scs/GrsrJ x CAST/EiJ)F1

limbs/digits/tail

short tail ( J:202091 )

• somewhat stumpy and sometimes kinked tail approximately three quarters of an inch in length

skeleton

abnormal axial skeleton morphology ( J:202091 )

• shortened, compacted body due to abnormal axial skeleton development

abnormal skeleton development ( J:202091 )