Phenotypes associated with this allele

• Allele Symbol: Gnrhr^{tm1(GNRHR1)Xen}
• Allele Name: targeted mutation 1, Taconic Biosciences
• Allele ID: MGI:5517591
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gnrhr^tm1(GNRHR1)Xen/Gnrhr^tm1(GNRHR1)Xen	involves: C57BL/6 * C57BL/6JOlaHsd	MGI:5517593

Genotype
MGI:5517593

hm1

• Allelic Composition: Gnrhr^{tm1(GNRHR1)Xen}/Gnrhr^{tm1(GNRHR1)Xen}
• Genetic Background: involves: C57BL/6 * C57BL/6JOlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:199193 )

N • female mice exhibit normal puberty, uterine morphology and ovarian morphology

N • male mice exhibit normal testicular development

abnormal estrous cycle ( J:199193 )

♀ • variable length

prolonged metestrus ( J:199193 )

♀ • in some mice

prolonged estrous cycle ( J:199193 )

♀ • in some mice

reduced female fertility ( J:199193 )

♀ • with longer periods between litters despite normal puberty

homeostasis/metabolism

decreased circulating testosterone level ( J:199193 )

♂ • following GnRH challenge

increased circulating estradiol level ( J:199193 )

♀ • basal levels in female mice

abnormal luteinizing hormone level ( J:199193 )

♂ • following gonadectomy, male mice fail to exhibit an increase in circulating luteinizing hormone unlike wild-type mice

decreased circulating luteinizing hormone level ( J:199193 )

• in male and female mice following GnRH challenge

abnormal response to injury ( J:199193 )

♂ • following gonadectomy, male mice fail to exhibit an increase in circulating luteinizing hormone unlike wild-type mice