Phenotypes associated with this allele

• Allele Symbol: Lmnb1^tm2Sgy
• Allele Name: targeted mutation 2, Stephen G Young
• Allele ID: MGI:5517592
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lmnb1^tm2Sgy/Lmnb1^tm2Sgy	involves: 129P2/OlaHsd * C57BL/6	MGI:5517694

Genotype
MGI:5517694

hm1

• Allelic Composition: Lmnb1^tm2Sgy/Lmnb1^tm2Sgy
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:197315 )

• mice die soon after birth

cellular

abnormal cell nucleus morphology ( J:197315 )

• 30% of mouse embryonic fibroblasts have abnormal nuclear morphology

craniofacial

abnormal cranium morphology ( J:197315 )

• flattened cranium

flat head ( J:197315 )

• newborns and E19.5 embryos are nearly normal in size but have a flattened cranium

nervous system

decreased brain size ( J:197315 )

• over all reduced size

decreased midbrain size ( J:197315 )

• 21.5% smaller than controls

abnormal stratification in cerebral cortex ( J:197315 )

• abnormal layering of cortical neurons

abnormal neuron morphology ( J:197315 )

• dumb bell shaped rather than round nuclei in neurons migrating out of neurospheres in culture

• asymmetric distribution of nuclear envelop proteins in neurons migrating out of neurospheres in culture

• midbrain neurons are elongated and have chromatin devoid of surrounding lamina

• cortex and midbrain with occasional neurons having dumbbell nuclei as seen in culture

respiratory system

abnormal lung development ( J:197315 )

• lungs less mature at birth

impaired lung alveolus development ( J:197315 )

• fewer alveoli at birth than are found in controls

skeleton

abnormal cranium morphology ( J:197315 )

• flattened cranium

growth/size/body

flat head ( J:197315 )

• newborns and E19.5 embryos are nearly normal in size but have a flattened cranium