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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Asb2tm1.1Lutz
targeted mutation 1.1, Pierre Lutz
MGI:5517670
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Asb2tm1.1Lutz/Asb2tm1.1Lutz
Tg(Mx1-cre)1Cgn/0 		involves: 129S2/SvPas * C57BL/6 * CBA MGI:5517671


Genotype
MGI:5517671
cn1
Allelic
Composition		 Asb2tm1.1Lutz/Asb2tm1.1Lutz
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Asb2tm1.1Lutz mutation (0 available); any Asb2 mutation (23 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal dendritic cell physiology ( J:200966 )
• immature dendritic cells from pIpC-treated mice exhibit reduced spreading on a fibronectin coated surface, rosette podosome formation, ability to degrade the extracellular matrix and migrate through matrigel-coated filters compared with wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory