Phenotypes associated with this allele

• Allele Symbol: Tg(Csf1r-HBEGF/mCherry)1Mnz
• Allele Name: transgene insertion 1, Michel C Nussenzweig
• Allele ID: MGI:5517795
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lyz2^tm1(cre)Ifo/Lyz2^tm1(cre)Ifo Tg(Csf1r-HBEGF/mCherry)1Mnz/0	B6.Cg-Lyz2^tm1(cre)Ifo Tg(Csf1r-HBEGF/mCherry)1Mnz/J	MGI:7334743

Genotype
MGI:7334743

cn1

• Allelic Composition: Lyz2^tm1(cre)Ifo/Lyz2^tm1(cre)Ifo; Tg(Csf1r-HBEGF/mCherry)1Mnz/0
• Genetic Background: B6.Cg-Lyz2^tm1(cre)Ifo Tg(Csf1r-HBEGF/mCherry)1Mnz/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased mechanical nociceptive threshold ( J:326965 )

• in mice treated with diphtheria toxin following injection of carrageenan

• treatment with dexamethasone does not prevent carrageenan-triggered inflammatory-related mechanical hypersensitivity

abnormal nociception after inflammation ( J:326965 )

• following injection of carrageenan, female and male mice treated with diphtheria toxin exhibit failure to resolve inflammatory mechanical hyperalgesia, thermal hyperalgesia, and posture changes related to inflammatory pain compared with control mice

• mice treated with diphtheria toxin fail to resolve complete Freunds adjuvant-induced transient inflammatory hyperalgesia unlike control mice

• treatment with dexamethasone does not prevent carrageenan-triggered inflammatory-related mechanical hypersensitivity

• macrophages lacking Il4ra, Stat6, or Cd200r1 fail to resolve inflammatory hyperalgesia

• however, carrageenan-induced inflammation is resolved in diphtheria toxin-treated mice and hyperalgesia was rescued by injection of in vitro differentiated bone marrow-derived macrophages and macrophages differentiated with IL-4

decreased thermal nociceptive threshold ( J:326965 )

• in mice treated with diphtheria toxin following injection of carrageenan