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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pygo1tm1.1Kba
targeted mutation 1.1, Konrad Basler
MGI:5518424
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pygo1tm1.1Kba/Pygo1tm1.1Kba involves: 129S6/SvEvTac * C57BL/6N * C57BL/6NTac MGI:5518436
cx2
 		Pygo1tm1.1Kba/Pygo1tm1.1Kba
Pygo2tm1.1Kba/Pygo2tm1.1Kba 		involves: 129S6/SvEvTac * C57BL/6N * C57BL/6NTac MGI:5518434


Genotype
MGI:5518436
hm1
Allelic
Composition		 Pygo1tm1.1Kba/Pygo1tm1.1Kba
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6N * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo1tm1.1Kba mutation (0 available); any Pygo1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:198562 )
N
• mice are born in expected Mendelian ratios




Genotype
MGI:5518434
cx2
Allelic
Composition		 Pygo1tm1.1Kba/Pygo1tm1.1Kba
Pygo2tm1.1Kba/Pygo2tm1.1Kba
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6N * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo1tm1.1Kba mutation (0 available); any Pygo1 mutation (21 available)
Pygo2tm1.1Kba mutation (0 available); any Pygo2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
oligozoospermia ( J:198562 )
• severe depletion of mature sperm cells in the lumen of most seminiferous tubules without a change in proliferation or apoptosis in the testis
abnormal spermatid morphology ( J:198562 )
• impaired nuclear condensation of elongating spermatids

mortality/aging
mortality/aging ( J:198562 )
N
• mice are born in expected Mendelian ratios

reproductive system
oligozoospermia ( J:198562 )
• severe depletion of mature sperm cells in the lumen of most seminiferous tubules without a change in proliferation or apoptosis in the testis
abnormal spermatid morphology ( J:198562 )
• impaired nuclear condensation of elongating spermatids
male infertility ( J:198562 )
• in some mice
reduced male fertility ( J:198562 )
• in some mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory