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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(Gli2)Jmao
targeted mutation 1, Junhao Mao
MGI:5518625
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(Gli2)Jmao/Gt(ROSA)26Sor+
Smotm2Amc/Smotm2Amc
Nkx3-2tm1(cre)Wez/Nkx3-2+ 		involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ MGI:5518632
cn2
 		Gt(ROSA)26Sortm1(Gli2)Jmao/Gt(ROSA)26Sor+
Nkx3-2tm1(cre)Wez/Nkx3-2+ 		involves: 129S7/SvEvBrd MGI:5518631


Genotype
MGI:5518632
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(Gli2)Jmao/Gt(ROSA)26Sor+
Smotm2Amc/Smotm2Amc
Nkx3-2tm1(cre)Wez/Nkx3-2+
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Gli2)Jmao mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Nkx3-2tm1(cre)Wez mutation (0 available); any Nkx3-2 mutation (21 available)
Smotm2Amc mutation (1 available); any Smo mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Gli2 expression, but not Gli3 de-repression, rescues intestinal phenotypes in Smotm2Amc/Smotm2Amc Nkx3-2tm1(cre)Wez/Nkx3-2+ embryos

digestive/alimentary system
digestive/alimentary phenotype ( J:199664 )
N
• intestinal development is rescued




Genotype
MGI:5518631
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(Gli2)Jmao/Gt(ROSA)26Sor+
Nkx3-2tm1(cre)Wez/Nkx3-2+
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Gli2)Jmao mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Nkx3-2tm1(cre)Wez mutation (0 available); any Nkx3-2 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Gli2 expression, but not Gli3 de-repression, rescues intestinal phenotypes in Smotm2Amc/Smotm2Amc Nkx3-2tm1(cre)Wez/Nkx3-2+ embryos

digestive/alimentary system
digestive/alimentary phenotype ( J:199664 )
N
• mice exhibit normal intestinal development




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory