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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itm2atm1.2Buck
targeted mutation 1.2, Margaret E Buckingham
MGI:5518653
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Itm2atm1.2Buck/Itm2atm1.2Buck involves: BALB/c * C57BL/6 MGI:5518666
cx2
 		Itm2atm1.2Buck/Y
Pax3tm4Buck/Pax3tm4Buck 		involves: C57BL/6 MGI:5518669
ot3
 		Itm2atm1.2Buck/Y involves: BALB/c * C57BL/6 MGI:5518665


Genotype
MGI:5518666
hm1
Allelic
Composition		 Itm2atm1.2Buck/Itm2atm1.2Buck
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2atm1.2Buck mutation (0 available); any Itm2a mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:200546 )
• viable and fertile with no obvious phenotype and normal adult myogenesis




Genotype
MGI:5518669
cx2
Allelic
Composition		 Itm2atm1.2Buck/Y
Pax3tm4Buck/Pax3tm4Buck
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2atm1.2Buck mutation (0 available); any Itm2a mutation (7 available)
Pax3tm4Buck mutation (0 available); any Pax3 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Phenotypic analysis of Itm2a mutant embryos

embryo
abnormal neural tube morphology ( J:200546 )
• authors state that mice display a classic Pax3 mutant phenotype

nervous system
abnormal neural tube morphology ( J:200546 )
• authors state that mice display a classic Pax3 mutant phenotype




Genotype
MGI:5518665
ot3
Allelic
Composition		 Itm2atm1.2Buck/Y
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2atm1.2Buck mutation (0 available); any Itm2a mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:200546 )
• viable and fertile with no obvious phenotype and normal adult myogenesis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory