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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il7tm1.1Mysl
targeted mutation 1.1, Myeong Sup Lee
MGI:5518726
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il7tm1.1Mysl/Il7tm1.1Mysl B6.129P2(Cg)-Il7tm1.1Mysl MGI:5518773
ht2
 		Il7tm1.1Mysl/Il7+ B6.129P2(Cg)-Il7tm1.1Mysl MGI:5518774


Genotype
MGI:5518773
hm1
Allelic
Composition		 Il7tm1.1Mysl/Il7tm1.1Mysl
Genetic
Background		 B6.129P2(Cg)-Il7tm1.1Mysl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il7tm1.1Mysl mutation (0 available); any Il7 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:200544 )
N
• mice exhibit normal spleens
arrested B cell differentiation ( J:200544 )
• at the pre-pro B cell stage
decreased T cell number ( J:200544 )
• CD3+ T lymphocytes in the periphery
decreased thymocyte number ( J:200544 )
• mature single positive thymocytes
abnormal mesenteric lymph node morphology ( J:200544 )
• reduced frequency
• however, mice exhibit normal macroscopic appearance and size
small lymph nodes ( J:200544 )
• absent or small with the exception of mesenteric nodes

hematopoietic system
arrested B cell differentiation ( J:200544 )
• at the pre-pro B cell stage
decreased T cell number ( J:200544 )
• CD3+ T lymphocytes in the periphery
decreased thymocyte number ( J:200544 )
• mature single positive thymocytes

endocrine/exocrine glands
decreased thymocyte number ( J:200544 )
• mature single positive thymocytes




Genotype
MGI:5518774
ht2
Allelic
Composition		 Il7tm1.1Mysl/Il7+
Genetic
Background		 B6.129P2(Cg)-Il7tm1.1Mysl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il7tm1.1Mysl mutation (0 available); any Il7 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell number ( J:200544 )
• modest reduction in CD3+ T lymphocytes in the periphery
small lymph nodes ( J:200544 )
• slightly

hematopoietic system
decreased T cell number ( J:200544 )
• modest reduction in CD3+ T lymphocytes in the periphery




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory