Phenotypes associated with this allele

• Allele Symbol: Ilk^tm10.1Ref
• Allele Name: targeted mutation 10.1, Reinhard Fassler
• Allele ID: MGI:5518827
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ilk^tm10.1Ref/Ilk^tm10.1Ref	B6.129(Cg)-Ilk^tm10.1Ref	MGI:5518840

Genotype
MGI:5518840

hm1

• Allelic Composition: Ilk^tm10.1Ref/Ilk^tm10.1Ref
• Genetic Background: B6.129(Cg)-Ilk^tm10.1Ref

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ilk^tm10.1Ref/Ilk^tm10.1Ref embryos display developmental delays and defective yolk sac vasculogenesis

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:199658 )

• mice die between E8 and E12.5

embryonic lethality between somite formation and embryo turning, incomplete penetrance ( J:199658 )

• mice die between E8 and E12.5

embryo

absent vitelline blood vessels ( J:199658 )

• lack of distal vascular structures at E8.5

• absent at E9.5 and later

• however, proximal blood islands are present at E8.5 and dilated primitive plexus at E9.5

delayed embryo turning ( J:199658 )

embryonic growth retardation ( J:199658 )

• slight at E8 indicated by the amnion not being fully closed

• at E8.5 with mice still in the head fold stage

cardiovascular system

absent vitelline blood vessels ( J:199658 )

• lack of distal vascular structures at E8.5

• absent at E9.5 and later

• however, proximal blood islands are present at E8.5 and dilated primitive plexus at E9.5

growth/size/body

embryonic growth retardation ( J:199658 )

• slight at E8 indicated by the amnion not being fully closed

• at E8.5 with mice still in the head fold stage