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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm1.1Thst
targeted mutation 1.1, Thorsten Stiewe
MGI:5518934
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp53tm1.1Thst/Trp53tm1.1Thst involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:5518941
ht2
 		Trp53tm1.1Thst/Trp53+ involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:5518942
ht3
 		Trp53tm1Thst/Trp53tm1.1Thst involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:5518943
cx4
 		Trp53tm1.1Thst/Trp53+
Tg(IghMyc)22Bri/0 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL * SJL MGI:5518944


Genotype
MGI:5518941
hm1
Allelic
Composition		 Trp53tm1.1Thst/Trp53tm1.1Thst
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1.1Thst mutation (1 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:198482 )
• median survival is 361 days compared with over 770 days for wild-type mice

neoplasm
increased tumor incidence ( J:198482 )
• mice develop fewer hematological malignancy compared with Trp53tm1Thst homozygotes

immune system
immune system phenotype ( J:198482 )
N
• mice exhibit normal thymic senescence staining and reactive oxygen species levels
decreased thymocyte apoptosis ( J:198482 )
• following gamma irradiation
• however, apoptosis response to dexamethasone is normal
spleen hyperplasia ( J:198482 )
• nonmalignant in most mice

cellular
abnormal cell physiology ( J:198482 )
• mouse embryonic fibroblasts infected with retroviruses expressing E1A and HRasG12V exhibit increased tumor growth when injecgted subcutaneously in immunocompromised mice and tumors do not exhibit increased apoptosis after chemotherapy compared with when wild-type cells are used
decreased cellular sensitivity to gamma-irradiation ( J:198482 )
• following whole body gamma irradiation, mice are resistant to apoptosis in the thymus, developing cerebellum and intestinal crypt compared with wild-type mice
decreased thymocyte apoptosis ( J:198482 )
• following gamma irradiation
• however, apoptosis response to dexamethasone is normal

hematopoietic system
decreased thymocyte apoptosis ( J:198482 )
• following gamma irradiation
• however, apoptosis response to dexamethasone is normal
spleen hyperplasia ( J:198482 )
• nonmalignant in most mice

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:198482 )
• following gamma irradiation
• however, apoptosis response to dexamethasone is normal

growth/size/body
spleen hyperplasia ( J:198482 )
• nonmalignant in most mice

muscle




Genotype
MGI:5518942
ht2
Allelic
Composition		 Trp53tm1.1Thst/Trp53+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1.1Thst mutation (1 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:198482 )
• median survival is 587 days compared with over 770 days for wild-type mice

neoplasm
increased tumor incidence ( J:198482 )
• malignant neoplasia in the spleen

immune system
spleen hyperplasia ( J:198482 )
• nonmalignant

hematopoietic system
spleen hyperplasia ( J:198482 )
• nonmalignant

growth/size/body
spleen hyperplasia ( J:198482 )
• nonmalignant




Genotype
MGI:5518943
ht3
Allelic
Composition		 Trp53tm1Thst/Trp53tm1.1Thst
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1.1Thst mutation (1 available); any Trp53 mutation (240 available)
Trp53tm1Thst mutation (2 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:198482 )
• median survival is 274 days compared with over 770 days for wild-type mice

neoplasm
increased tumor incidence ( J:198482 )
• malignant neoplasia in the spleen in most mice

immune system
spleen hyperplasia ( J:198482 )
• nonmalignant in a few mice

hematopoietic system
spleen hyperplasia ( J:198482 )
• nonmalignant in a few mice

growth/size/body
spleen hyperplasia ( J:198482 )
• nonmalignant in a few mice




Genotype
MGI:5518944
cx4
Allelic
Composition		 Trp53tm1.1Thst/Trp53+
Tg(IghMyc)22Bri/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghMyc)22Bri mutation (1 available)
Trp53tm1.1Thst mutation (1 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:198482 )
• compared with Tg(IghMyc)22Bri mice
• median survival is 10 days longer than in Trp53tm1Thst/Trp53+ Tg(IghMyc)22Bri mice

neoplasm
increased lymphoma incidence ( J:198482 )
• with increased apoptosis and senescence staining in tumors from Tg(IghMyc)22Bri mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory