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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm1Thst
targeted mutation 1, Thorsten Stiewe
MGI:5518935
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp53tm1Thst/Trp53tm1Thst involves: 129S1/Sv * 129X1/SvJ MGI:5518939
ht2
 		Trp53tm1Thst/Trp53+ involves: 129S1/Sv * 129X1/SvJ MGI:5518940
ht3
 		Trp53tm1Thst/Trp53tm1.1Thst involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:5518943
cx4
 		Trp53tm1Thst/Trp53+
Tg(IghMyc)22Bri/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL * SJL MGI:5518945


Genotype
MGI:5518939
hm1
Allelic
Composition		 Trp53tm1Thst/Trp53tm1Thst
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Thst mutation (2 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:198482 )
• median survival is 131 days compared with over 770 days for wild-type mice

neoplasm
increased tumor incidence ( J:198482 )
• mice develop more hematological malignancy compared with Trp53tm1.1Thst homozygotes

immune system
decreased thymocyte apoptosis ( J:198482 )
• following gamma irradiation
• however, apoptosis response to dexamethasone is normal

cellular
abnormal cell physiology ( J:198482 )
• mouse embryonic fibroblasts infected with retroviruses expressing E1A and HRasG12V exhibit increased tumor growth when injected subcutaneously in immunocompromised mice compared with wild-type mice
decreased cellular sensitivity to gamma-irradiation ( J:198482 )
• following whole body gamma irradiation, mice are resistant to apoptosis in the thymus, developing cerebellum and intestinal crypt compared with wild-type mice
decreased thymocyte apoptosis ( J:198482 )
• following gamma irradiation
• however, apoptosis response to dexamethasone is normal
oxidative stress ( J:198482 )
• thymocytes exhibit increased reactive oxygen species levels compared with wild-type cells

hematopoietic system
decreased thymocyte apoptosis ( J:198482 )
• following gamma irradiation
• however, apoptosis response to dexamethasone is normal

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:198482 )
• following gamma irradiation
• however, apoptosis response to dexamethasone is normal




Genotype
MGI:5518940
ht2
Allelic
Composition		 Trp53tm1Thst/Trp53+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Thst mutation (2 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:198482 )
• median survival is 438 days compared with over 770 days for wild-type mice

neoplasm
increased tumor incidence ( J:198482 )
• malignant neoplasia in the spleen of most mice

immune system
spleen hyperplasia ( J:198482 )
• nonmalignant in a few mice

hematopoietic system
spleen hyperplasia ( J:198482 )
• nonmalignant in a few mice

growth/size/body
spleen hyperplasia ( J:198482 )
• nonmalignant in a few mice




Genotype
MGI:5518943
ht3
Allelic
Composition		 Trp53tm1Thst/Trp53tm1.1Thst
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1.1Thst mutation (1 available); any Trp53 mutation (240 available)
Trp53tm1Thst mutation (2 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:198482 )
• median survival is 274 days compared with over 770 days for wild-type mice

neoplasm
increased tumor incidence ( J:198482 )
• malignant neoplasia in the spleen in most mice

immune system
spleen hyperplasia ( J:198482 )
• nonmalignant in a few mice

hematopoietic system
spleen hyperplasia ( J:198482 )
• nonmalignant in a few mice

growth/size/body
spleen hyperplasia ( J:198482 )
• nonmalignant in a few mice




Genotype
MGI:5518945
cx4
Allelic
Composition		 Trp53tm1Thst/Trp53+
Tg(IghMyc)22Bri/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghMyc)22Bri mutation (1 available)
Trp53tm1Thst mutation (2 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:198482 )
• compared with Tg(IghMyc)22Bri mice

neoplasm




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory