Phenotypes associated with this allele

• Allele Symbol: Ryr2^tm2.1Msnr
• Allele Name: targeted mutation 2.1, Gerhard Meissner
• Allele ID: MGI:5518958
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ryr2^tm2.1Msnr/Ryr2^tm2.1Msnr	129S.129P2-Ryr2^tm2.1Msnr	MGI:5519036

Genotype
MGI:5519036

hm1

• Allelic Composition: Ryr2^tm2.1Msnr/Ryr2^tm2.1Msnr
• Genetic Background: 129S.129P2-Ryr2^tm2.1Msnr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:200958 )

N • mice exhibit normal heart rate, fractional shortening, interventricular septum and left ventricular diastolic and systolic posterior wall thickness

N • cardiac muscle sarcoplasmic calcium ion handling is normal

thick interventricular septum ( J:200958 )

• increased interventricular septum diastolic and systolic thickness following transverse aortic constriction

increased heart weight ( J:200958 )

• at 6 to 7 months

• 1.4-fold following transverse aortic constriction compared with 1.1-fold in wild-type mice

cardiac hypertrophy ( J:200958 )

• modest

• modest following pressure overload by transverse aortic constriction

abnormal heart left ventricle morphology ( J:200958 )

• increased left ventricular posterior diastolic and systolic wall thicknesses

• increased left ventricular posterior diastolic wall thickness following transverse aortic constriction

abnormal heart right ventricle morphology ( J:200958 )

• decreased wall thickness and cross-sectional area

thick ventricular wall ( J:200958 )

• modest in the right ventricle

growth/size/body

increased heart weight ( J:200958 )

• at 6 to 7 months

• 1.4-fold following transverse aortic constriction compared with 1.1-fold in wild-type mice

cardiac hypertrophy ( J:200958 )

• modest

• modest following pressure overload by transverse aortic constriction