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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lin28btm1.1Gqda
targeted mutation 1.1, George Q Daley
MGI:5519055
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lin28btm1.1Gqda/Lin28btm1.1Gqda involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N MGI:5519068
cn2
 		Lin28btm1Gqda/Lin28btm1.1Gqda
Ndor1Tg(UBC-cre/ERT2)1Ejb/0 		involves: 129S/SvEv * 129S4/SvJae * C57BL/6 MGI:5519073
cx3
 		Lin28atm1.1Gqda/Lin28a+
Lin28btm1.1Gqda/Lin28btm1.1Gqda 		involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N MGI:5519070
cx4
 		Lin28atm1.1Gqda/Lin28atm1.1Gqda
Lin28btm1.1Gqda/Lin28btm1.1Gqda 		involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N MGI:5519071
cx5
 		Lin28btm1.1Gqda/Lin28btm1.1Gqda
Tsc1tm1.1Djk/Tsc1+ 		involves: 129S4/SvJae * C57BL/6 * FVB MGI:5519080


Genotype
MGI:5519068
hm1
Allelic
Composition		 Lin28btm1.1Gqda/Lin28btm1.1Gqda
Genetic
Background		 involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin28btm1.1Gqda mutation (1 available); any Lin28b mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:199720 )
• postnatal dwarfism in male, but not female, mice




Genotype
MGI:5519073
cn2
Allelic
Composition		 Lin28btm1Gqda/Lin28btm1.1Gqda
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin28btm1.1Gqda mutation (1 available); any Lin28b mutation (23 available)
Lin28btm1Gqda mutation (0 available); any Lin28b mutation (23 available)
Ndor1Tg(UBC-cre/ERT2)1Ejb mutation (6 available); any Ndor1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:199720 )
N
• mice exhibit normal growth when treated with tamoxifen at 7 to 9 days or 6 weeks of age
decreased body size ( J:199720 )
• postnatal dwarfism in male, but not female, mice treated with tamoxifen at E15.5




Genotype
MGI:5519070
cx3
Allelic
Composition		 Lin28atm1.1Gqda/Lin28a+
Lin28btm1.1Gqda/Lin28btm1.1Gqda
Genetic
Background		 involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin28atm1.1Gqda mutation (1 available); any Lin28a mutation (76 available)
Lin28btm1.1Gqda mutation (1 available); any Lin28b mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:199720 )
• dwarfism in female and male mice




Genotype
MGI:5519071
cx4
Allelic
Composition		 Lin28atm1.1Gqda/Lin28atm1.1Gqda
Lin28btm1.1Gqda/Lin28btm1.1Gqda
Genetic
Background		 involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin28atm1.1Gqda mutation (1 available); any Lin28a mutation (76 available)
Lin28btm1.1Gqda mutation (1 available); any Lin28b mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
open neural tube ( J:199720 )
• in 2 of 7 at E11.5
abnormal forebrain development ( J:199720 )
• poor development
collapsed brain ventricles ( J:199720 )
• collapsed ventricle

growth/size/body
embryonic growth retardation ( J:199720 )
• indicated by fewer somites at E10.5 and open neural tube in some mice at E11.5
decreased embryo size ( J:199720 )
• at E9.5 and E10.5

embryo
embryonic growth retardation ( J:199720 )
• indicated by fewer somites at E10.5 and open neural tube in some mice at E11.5
decreased embryo size ( J:199720 )
• at E9.5 and E10.5
open neural tube ( J:199720 )
• in 2 of 7 at E11.5




Genotype
MGI:5519080
cx5
Allelic
Composition		 Lin28btm1.1Gqda/Lin28btm1.1Gqda
Tsc1tm1.1Djk/Tsc1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin28btm1.1Gqda mutation (1 available); any Lin28b mutation (23 available)
Tsc1tm1.1Djk mutation (1 available); any Tsc1 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:199720 )
N
• male mice exhibit normal growth




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory