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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Defb3tm1Xen
targeted mutation 1, Taconic Biosciences
MGI:5519129
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Defb3tm1Xen/Defb3tm1Xen involves: C57BL/6 MGI:5519131


Genotype
MGI:5519131
hm1
Allelic
Composition		 Defb3tm1Xen/Defb3tm1Xen
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Defb3tm1Xen mutation (0 available); any Defb3 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased neutrophil cell number ( J:199719 )
• in the cornea of mice infected with F. solani
increased incidence of corneal inflammation ( J:199719 )
• in mice infected with F. solani
increased susceptibility to fungal infection ( J:199719 )
• mice infected with F. solani exhibit increased severity of keratitis (cornea cloudiness, edema, descemetocele formation and cornea perforation), increased neutrophil infiltration (determined by MPO activity and plate count) and enhanced fungal load without recovery compared with wild-type mice

vision/eye
increased incidence of corneal inflammation ( J:199719 )
• in mice infected with F. solani

hematopoietic system
increased neutrophil cell number ( J:199719 )
• in the cornea of mice infected with F. solani




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory