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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Arid5atm1Rnis
targeted mutation 1, Riko Nishimura
MGI:5519212
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Arid5atm1Rnis/Arid5atm1Rnis B6.Cg-Arid5atm1Rnis MGI:5519214


Genotype
MGI:5519214
hm1
Allelic
Composition		 Arid5atm1Rnis/Arid5atm1Rnis
Genetic
Background		 B6.Cg-Arid5atm1Rnis
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid5atm1Rnis mutation (1 available); any Arid5a mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T-helper 17 cell number ( J:197418 )
• after lipopolysaccharide injection relative to levels in control mice
increased T cell number ( J:197418 )
• IFN-gamma producing T cells are increased after lipopolysaccharide injection relative to levels in control mice
decreased circulating interleukin-6 level ( J:197418 )
• serum levels are significantly reduced after lipopolysaccharide injection relative to levels in control mice
decreased circulating tumor necrosis factor level ( J:197418 )
• slightly reduced after lipopolysaccharide injection relative to levels in control mice
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:197418 )
• significantly suppressed after lipopolysaccharide injection relative to levels in control mice

homeostasis/metabolism
decreased circulating interleukin-6 level ( J:197418 )
• serum levels are significantly reduced after lipopolysaccharide injection relative to levels in control mice
decreased circulating tumor necrosis factor level ( J:197418 )
• slightly reduced after lipopolysaccharide injection relative to levels in control mice

hematopoietic system
decreased T-helper 17 cell number ( J:197418 )
• after lipopolysaccharide injection relative to levels in control mice
increased T cell number ( J:197418 )
• IFN-gamma producing T cells are increased after lipopolysaccharide injection relative to levels in control mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory