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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ninj1tm1b(KOMP)Wtsi
targeted mutation 1b, Wellcome Trust Sanger Institute
MGI:5519238
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ninj1tm1b(KOMP)Wtsi/Ninj1tm1b(KOMP)Wtsi involves: C57BL/6N * FVB/N MGI:5519889
ht2
 		Ninj1tm1b(KOMP)Wtsi/Ninj1+ involves: C57BL/6N * FVB/N MGI:5519890


Genotype
MGI:5519889
hm1
Allelic
Composition		 Ninj1tm1b(KOMP)Wtsi/Ninj1tm1b(KOMP)Wtsi
Genetic
Background		 involves: C57BL/6N * FVB/N
Cell Lines EPD0095_2_C02
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ninj1tm1b(KOMP)Wtsi mutation (0 available); any Ninj1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:197409 )
• mice are all dead by 71 days of age

cellular
abnormal cellular replicative senescence ( J:197409 )
• increased levels of cellular senescence in cultured MEFs

nervous system




Genotype
MGI:5519890
ht2
Allelic
Composition		 Ninj1tm1b(KOMP)Wtsi/Ninj1+
Genetic
Background		 involves: C57BL/6N * FVB/N
Cell Lines EPD0095_2_C02
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ninj1tm1b(KOMP)Wtsi mutation (0 available); any Ninj1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased cellular sensitivity to gamma-irradiation ( J:197409 )
• median survival after 8Gy of gamma irradiation is 13 days compared to 19 days for controls
• mice are normal otherwise




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory