Phenotypes associated with this allele

• Allele Symbol: Ninj1^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5519238
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ninj1^tm1b(KOMP)Wtsi/Ninj1^tm1b(KOMP)Wtsi	involves: C57BL/6N * FVB/N	MGI:5519889
ht2	Ninj1^tm1b(KOMP)Wtsi/Ninj1^+	involves: C57BL/6N * FVB/N	MGI:5519890

Genotype
MGI:5519889

hm1

• Allelic Composition: Ninj1^{tm1b(KOMP)Wtsi}/Ninj1^{tm1b(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N * FVB/N
• Cell Lines: EPD0095_2_C02

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:197409 )

• mice are all dead by 71 days of age

cellular

abnormal cellular replicative senescence ( J:197409 )

• increased levels of cellular senescence in cultured MEFs

nervous system

hydrocephaly ( J:197409 )

Genotype
MGI:5519890

ht2

• Allelic Composition: Ninj1^{tm1b(KOMP)Wtsi}/Ninj1⁺
• Genetic Background: involves: C57BL/6N * FVB/N
• Cell Lines: EPD0095_2_C02

cellular

increased cellular sensitivity to gamma-irradiation ( J:197409 )

• median survival after 8Gy of gamma irradiation is 13 days compared to 19 days for controls

• mice are normal otherwise