All Phenotypes Edn2<tm1Ywa> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Edn2^tm1Ywa/Edn2^tm1Ywa	involves: 129S6/SvEvTac	MGI:5519891
hm2	Edn2^tm1Ywa/Edn2^tm1Ywa	involves: 129S6/SvEvTac * C57BL/6	MGI:7281185

Allelic Composition	Edn2^tm1Ywa/Edn2^tm1Ywa
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edn2^tm1Ywa mutation (1 available); any Edn2 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Decreased body weight in Edn2^tm1Ywa/Edn2^tm1Ywa mice

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:201436 )

• when housed at 22 degrees Celsius

premature death ( J:201436 )

• mice die by 3 to 4 weeks of age

• not rescued by thyroid hormone replacement

• however, mice housed at a higher temperature exhibit extended lifespan to 9 weeks

postnatal lethality, incomplete penetrance ( J:201436 )

• mice die by 3 to 4 weeks of age

• not rescued by thyroid hormone replacement

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:201436 )

N	• mice exhibit normal serum insulin levels and secretion

impaired adaptive thermogenesis ( J:201436 )

• decreased body temperature in response to cold exposure

• mice exhibit a preference for a warmer temperature location than wild-type mice

abnormal blood homeostasis ( J:201436 )

decreased circulating triiodothyronine level ( J:201436 )

• mild

acidemia ( J:201436 )

• blood pH is more acidic

increased blood urea nitrogen level ( J:201436 )

increased blood uric acid level ( J:201436 )

increased circulating bicarbonate level ( J:201436 )

decreased circulating glucose level ( J:201436 )

• under fed conditions

increased circulating erythropoietin level ( J:201436 )

increased circulating ketone body level ( J:201436 )

decreased body temperature ( J:201436 )

• mild hypothermia

abnormal gas homeostasis ( J:201436 )

hypercapnia ( J:201436 )

hypoxia ( J:201436 )

• hypoxemic hypoxia

acidosis ( J:201436 )

• blood pH is more acidic

abnormal lipolysis ( J:201436 )

• cold-exposed mice fail to exhibit enhanced lipolysis unlike wild-type mice

growth/size/body

decreased body size ( J:201436 )

• at 2 weeks

decreased body weight ( J:201436 )

• beginning at P5

postnatal growth retardation ( J:201436 )

• severe by P5

• not rescued by thyroid hormone replacement

respiratory system

abnormal pulmonary alveolar sac morphology ( J:201436 )

abnormal pulmonary alveolus morphology ( J:201436 )

• simplified structure

increased total lung capacity ( J:201436 )

adipose tissue

abnormal brown adipose tissue morphology ( J:201436 )

• reduced nuclei number and increased large lipid vacuoles in cold-exposed mice

digestive/alimentary system

digestive/alimentary phenotype ( J:201436 )

N	• mice exhibit normal fat and carbohydrate absorption and excretion

hematopoietic system

increased hematocrit ( J:201436 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:215159 )

• mice exhibit a low survival rate past weaning

premature death ( J:215159 )

• mice exhibit shorter life spans than control littermates

• however, a few mice can survive up to the age of 7 weeks when kept on a 30 degrees Celcius warm pad starting from weaning

growth/size/body

decreased body size ( J:215159 )

• mice have a smaller physique than control littermates

behavior/neurological

weakness ( J:215159 )

• mice exhibit poor health and weakness

reproductive system

impaired luteal cell differentiation ( J:215159 )

• at 24 hrs hCG injection (hCG24), no polyhedral luteal cells are seen in corpora lutea

• instead, multiple large Graafian follicles are present in the periphery of ovaries; some, but not all, contain an oocyte with a partial or complete cumulus layer

absent corpus luteum ( J:215159 )

• at 5-7 weeks of age, no corpora lutea are observed in the absence of gonadotropin stimulation

• at 24 hrs hCG injection (hCG24), no vascularized corpora lutea are present even in ovaries that are capable of releasing one or multiple oocytes

• however, follicular development is qualitatively normal in unstimulated post-pubertal females

• no excessive atresia is detected in ovaries from P25 superovulated females by Caspase-3 staining at 16 hrs after hCG injection (hCG16)

abnormal ovarian medulla morphology ( J:215159 )

• at 5-7 weeks of age, 3 of 5 ovaries exhibit a varying degree of vascular congestion

• however, ovaries from P25 superovulated females show normal endothelial cell (PECAM1, aka CD31) staining at hCG16

small ovary ( J:215159 )

• ovaries collected from P23-P31 females at the time of euthanasia 24 hrs after superovulation are smaller than in heterozygote control siblings

small uterus ( J:215159 )

• uteri collected from P23-P31 females at the time of euthanasia 24 hrs after superovulation are smaller than in heterozygote control siblings

decreased superovulation rate ( J:215159 )

• at hCG24, only 2 of 6 females tested had 1 oocyte each in one of their oviducts versus an average of 20.5 +/- 1.7 oocytes per ovary in heterozygote controls

• at 16 hrs after hCG injection (hCG16), only 1 oocyte was retrieved from one of 2 pre-pubertal females tested versus an average of 18.0 +/- 4.8 oocytes per ovary released from heterozygote controls

• however, at hCG24, two outlying females ovulated a normal range of oocytes

cardiovascular system

blood vessel congestion ( J:215159 )

• at 5-7 weeks of age, 3 of 5 ovaries exhibit a varying degree of vascular congestion

• however, ovaries from P25 superovulated females show normal endothelial cell (PECAM1, aka CD31) staining 16 hrs after hCG injection

homeostasis/metabolism

decreased circulating progesterone level ( J:215159 )

• at hCG24, serum progesterone concentrations are significantly lower than in heterozygote controls, even in females that ovulate a normal range of oocytes

endocrine/exocrine glands

impaired luteal cell differentiation ( J:215159 )

• at 24 hrs hCG injection (hCG24), no polyhedral luteal cells are seen in corpora lutea

• instead, multiple large Graafian follicles are present in the periphery of ovaries; some, but not all, contain an oocyte with a partial or complete cumulus layer

absent corpus luteum ( J:215159 )

• at 5-7 weeks of age, no corpora lutea are observed in the absence of gonadotropin stimulation

• at 24 hrs hCG injection (hCG24), no vascularized corpora lutea are present even in ovaries that are capable of releasing one or multiple oocytes

• however, follicular development is qualitatively normal in unstimulated post-pubertal females

• no excessive atresia is detected in ovaries from P25 superovulated females by Caspase-3 staining at 16 hrs after hCG injection (hCG16)

abnormal ovarian medulla morphology ( J:215159 )

• at 5-7 weeks of age, 3 of 5 ovaries exhibit a varying degree of vascular congestion

• however, ovaries from P25 superovulated females show normal endothelial cell (PECAM1, aka CD31) staining at hCG16

small ovary ( J:215159 )

• ovaries collected from P23-P31 females at the time of euthanasia 24 hrs after superovulation are smaller than in heterozygote control siblings

cellular

impaired luteal cell differentiation ( J:215159 )

• at 24 hrs hCG injection (hCG24), no polyhedral luteal cells are seen in corpora lutea

• instead, multiple large Graafian follicles are present in the periphery of ovaries; some, but not all, contain an oocyte with a partial or complete cumulus layer

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