Phenotypes associated with this allele

• Allele Symbol: Prkci^tm1Ltg
• Allele Name: targeted mutation 1, Michael Leitges
• Allele ID: MGI:5520924
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkci^tm1Ltg/Prkci^tm1Ltg	involves: 129P2/OlaHsd * NMRI	MGI:5520951

Genotype
MGI:5520951

hm1

• Allelic Composition: Prkci^tm1Ltg/Prkci^tm1Ltg
• Genetic Background: involves: 129P2/OlaHsd * NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:202124 )

• mice are reabsorbed by E10.5

embryo

abnormal proximal-distal axis patterning ( J:202124 )

• at E7.5, embryos are compressed along the proximal-distal axis with small amniotic cavity compared with wild-type mice

abnormal rostral-caudal axis patterning ( J:202124 )

• lacking polarity at E8.5

embryonic growth retardation ( J:202124 )

• at E8.5

thick embryonic epiblast ( J:202124 )

abnormal head fold morphology ( J:202124 )

• reduced or absent at E8.5

absent somites ( J:202124 )

• at E8.5

absent allantois ( J:202124 )

• reduced or absent at E8.5

small allantois ( J:202124 )

• reduced or absent at E8.5

small amniotic cavity ( J:202124 )

cardiovascular system

abnormal heart tube morphology ( J:202124 )

• reduced or absent at E8.5

absent heart tube ( J:202124 )

• reduced or absent at E8.5

growth/size/body

embryonic growth retardation ( J:202124 )

• at E8.5