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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prss37tm1Zgwg
targeted mutation 1, Zhugang Wang
MGI:5520954
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prss37tm1Zgwg/Prss37tm1Zgwg involves: 129S6/SvEvTac * C57BL/6J MGI:5520959


Genotype
MGI:5520959
hm1
Allelic
Composition		 Prss37tm1Zgwg/Prss37tm1Zgwg
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss37tm1Zgwg mutation (0 available); any Prss37 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:202066 )
N
• female mice are fertile
• male mice exhibit normal spermatogenesis as well as normal sperm morphology, sperm motility and capacitation
impaired sperm migration in female genital tract ( J:202066 )
• impaired sperm migration from the uterus into the oviduct
impaired fertilization ( J:202066 )
• severely impaired fertilization in vivo (2.3% vs. 70% of that in control mice)
• however, sperm are able to fertilize cumulus-intact oocytes in vitro
impaired binding of sperm to zona pellucida ( J:202066 )
• in vitro, sperm are unable to bind zona-intact oocytes

cellular
impaired sperm migration in female genital tract ( J:202066 )
• impaired sperm migration from the uterus into the oviduct




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory