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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gal3st1tm1.1Hjg
targeted mutation 1.1, Herman-Josef Grone
MGI:5520956
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gal3st1tm1.1Hjg/Gal3st1tm1.1Hjg
Pax8tm1.1(cre)Mbu/Pax8+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:5521179
cn2
 		Gal3st1tm1.1Hjg/Gal3st1tm1.1Hjg
Ugcgtm1Hjg/Ugcgtm1Hjg
Pax8tm1.1(cre)Mbu/Pax8+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:5521180


Genotype
MGI:5521179
cn1
Allelic
Composition		 Gal3st1tm1.1Hjg/Gal3st1tm1.1Hjg
Pax8tm1.1(cre)Mbu/Pax8+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gal3st1tm1.1Hjg mutation (0 available); any Gal3st1 mutation (22 available)
Pax8tm1.1(cre)Mbu mutation (1 available); any Pax8 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:197393 )
N
• normal life span

renal/urinary system
renal/urinary system phenotype ( J:197393 )
N
• normal kidney morphology and creatinine clearance
decreased urine ammonia level ( J:197393 )
• decreased ammonium excretion
• reduced ability to increase urinary ammonia
decreased urine pH ( J:197393 )
• higher excretion of titratable acid relative to controls
• less ability to recover from high acid in the diet

homeostasis/metabolism
metabolic acidosis ( J:197393 )
• increased metabolic acidosis
decreased urine ammonia level ( J:197393 )
• decreased ammonium excretion
• reduced ability to increase urinary ammonia
decreased urine pH ( J:197393 )
• higher excretion of titratable acid relative to controls
• less ability to recover from high acid in the diet




Genotype
MGI:5521180
cn2
Allelic
Composition		 Gal3st1tm1.1Hjg/Gal3st1tm1.1Hjg
Ugcgtm1Hjg/Ugcgtm1Hjg
Pax8tm1.1(cre)Mbu/Pax8+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gal3st1tm1.1Hjg mutation (0 available); any Gal3st1 mutation (22 available)
Pax8tm1.1(cre)Mbu mutation (1 available); any Pax8 mutation (32 available)
Ugcgtm1Hjg mutation (0 available); any Ugcg mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:197393 )
N
• normal life span

renal/urinary system
renal/urinary system phenotype ( J:197393 )
N
• normal kidney morphology and creatinine clearance
decreased urine ammonia level ( J:197393 )
• decreased ammonium excretion
• reduced ability to increase urinary ammonia
decreased urine pH ( J:197393 )
• higher excretion of titratable acid relative to controls
• less ability to recover from high acid in the diet
abnormal kidney papilla morphology ( J:197393 )
• ammonium content of the renal papilla is reduced 30% compared to controls

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:197393 )
N
• normal blood pH
• normal blood bicarbonate levels
decreased urine ammonia level ( J:197393 )
• decreased ammonium excretion
• reduced ability to increase urinary ammonia
decreased urine pH ( J:197393 )
• higher excretion of titratable acid relative to controls
• less ability to recover from high acid in the diet




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory