All Phenotypes Sestd1<tm1.1Bnrc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sestd1^tm1.1Bnrc
targeted mutation 1.1, Benjamin Cheyette
MGI:5520962

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sestd1^tm1.1Bnrc/Sestd1^tm1.1Bnrc	involves: 129S6/SvEvTac * C57BL/6NCr	MGI:5520972
cx2	Sestd1^tm1.1Bnrc/Sestd1^tm1.1Bnrc Vangl2^Lp/Vangl2⁺	involves: 129S6/SvEvTac * A * C57BL/6NCr	MGI:5520977
cx3	Sestd1^tm1.1Bnrc/Sestd1⁺ Vangl2^Lp/Vangl2⁺	involves: 129S6/SvEvTac * A * C57BL/6NCr	MGI:5520978
cx4	Dact1^tm1.1Bnrc/Dact1^tm1.1Bnrc Sestd1^tm1.1Bnrc/Sestd1^tm1.1Bnrc	involves: 129S6/SvEvTac * C57BL/6NCr	MGI:5520973
cx5	Dact1^tm1.1Bnrc/Dact1^tm1.1Bnrc Sestd1^tm1.1Bnrc/Sestd1⁺	involves: 129S6/SvEvTac * C57BL/6NCr	MGI:5520974
cx6	Dact1^tm1.1Bnrc/Dact1⁺ Sestd1^tm1.1Bnrc/Sestd1^tm1.1Bnrc	involves: 129S6/SvEvTac * C57BL/6NCr	MGI:5520976

Allelic Composition	Sestd1^tm1.1Bnrc/Sestd1^tm1.1Bnrc
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sestd1^tm1.1Bnrc mutation (0 available); any Sestd1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Spectrum of posterior defects in Sestd1^tm1.1Bnrc/Sestd1^tm1.1Bnrc and Dact1^tm1.1Bnrc/Dact1^tm1.1Bnrc mice

mortality/aging

neonatal lethality, complete penetrance ( J:201925 )

reproductive system

abnormal genital tubercle morphology ( J:201925 )

• absent

embryo

abnormal embryo development ( J:201925 )

• more rounded posterior contour at E8.5 than in wild-type mice

abnormal neural tube morphology ( J:201925 )

• partly penetrant neural tube defects

spina bifida ( J:201925 )

• in some mice

renal/urinary system

hydronephrosis ( J:201925 )

absent urinary bladder ( J:201925 )

limbs/digits/tail

short tail ( J:201925 )

curly tail ( J:201925 )

• in some mice

digestive/alimentary system

absent anus ( J:201925 )

abnormal colon morphology ( J:201925 )

• blind-end

nervous system

abnormal neural tube morphology ( J:201925 )

• partly penetrant neural tube defects

spina bifida ( J:201925 )

• in some mice

Allelic Composition	Sestd1^tm1.1Bnrc/Sestd1^tm1.1Bnrc Vangl2^Lp/Vangl2⁺
Genetic Background	involves: 129S6/SvEvTac * A * C57BL/6NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sestd1^tm1.1Bnrc mutation (0 available); any Sestd1 mutation (32 available)
Vangl2^Lp mutation (2 available); any Vangl2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal reproductive system development ( J:201925 )

• genitourinary defects in 2 of 15 mice compared with 4 of 11 Sestd1^tm1.1Bnrc homozygotes

limbs/digits/tail

short tail ( J:201925 )

• in 1 of 15 mice

curly tail ( J:201925 )

• in 6 of 15 mice

renal/urinary system

abnormal urinary system development ( J:201925 )

• genitourinary defects in 2 of 15 mice compared with 4 of 11 Sestd1^tm1.1Bnrc homozygotes

Allelic Composition	Sestd1^tm1.1Bnrc/Sestd1⁺ Vangl2^Lp/Vangl2⁺
Genetic Background	involves: 129S6/SvEvTac * A * C57BL/6NCr

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

curly tail ( J:201925 )

• in 69 of 84 mice

Allelic Composition	Dact1^tm1.1Bnrc/Dact1^tm1.1Bnrc Sestd1^tm1.1Bnrc/Sestd1^tm1.1Bnrc
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dact1^tm1.1Bnrc mutation (0 available); any Dact1 mutation (21 available)
Sestd1^tm1.1Bnrc mutation (0 available); any Sestd1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal genital tubercle morphology ( J:201925 )

• absent

limbs/digits/tail

short tail ( J:201925 )

Allelic Composition	Dact1^tm1.1Bnrc/Dact1^tm1.1Bnrc Sestd1^tm1.1Bnrc/Sestd1⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCr

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal genital tubercle morphology ( J:201925 )

• absent

limbs/digits/tail

short tail ( J:201925 )

Allelic Composition	Dact1^tm1.1Bnrc/Dact1⁺ Sestd1^tm1.1Bnrc/Sestd1^tm1.1Bnrc
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCr

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal genital tubercle morphology ( J:201925 )

• absent

limbs/digits/tail

short tail ( J:201925 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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