All Phenotypes Ndufaf2<tm1.1Itl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ndufaf2^tm1.1Itl
targeted mutation 1.1, inGenious Targeting Laboratory
MGI:5521199

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ndufaf2^tm1.1Itl/Ndufaf2^tm1.1Itl	involves: 129S/SvEv * BALB/cJ	MGI:5521200

Allelic Composition	Ndufaf2^tm1.1Itl/Ndufaf2^tm1.1Itl
Genetic Background	involves: 129S/SvEv * BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndufaf2^tm1.1Itl mutation (1 available); any Ndufaf2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal mitochondrial ATP synthesis coupled electron transport ( J:201547 )

• skin fibroblasts exhibit decreased complex 1 activity in the mitochondria compared with wild-type cells

• however, skin fibroblasts exhibit complex 1 assembly in the mitochondria

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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