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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fcgr4tm1Rav
targeted mutation 1, Jeffrey V Ravetch
MGI:5521465
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fcgr4tm1Rav/Fcgr4tm1Rav
Tg(Ctsk-cre)1Rda/0 		involves: C57BL/6 MGI:5521480


Genotype
MGI:5521480
cn1
Allelic
Composition		 Fcgr4tm1Rav/Fcgr4tm1Rav
Tg(Ctsk-cre)1Rda/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr4tm1Rav mutation (0 available); any Fcgr4 mutation (26 available)
Tg(Ctsk-cre)1Rda mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:197378 )
N
• normal osteoclastogenesis in the presence of FCGR4 cross-linking antibodies
autoimmune arthritis ( J:197378 )
• no reduction in clinical signs of arthritis in the presence of FCGR4 cross-linking antibodies
decreased bone resorption ( J:197378 )
• reduced bone erosion in the presence of FCGR4 cross-linking antibodies

homeostasis/metabolism
abnormal circulating protein level ( J:197378 )
• reduced serum collagen 1 fragments in the presence of FCGR4 cross-linking antibodies

immune system
autoimmune arthritis ( J:197378 )
• no reduction in clinical signs of arthritis in the presence of FCGR4 cross-linking antibodies

hematopoietic system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory