All Phenotypes Egln1<tm2.1Fsl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Egln1^tm2.1Fsl
targeted mutation 2.1, Frank Lee
MGI:5521468

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Egln1^tm2.1Fsl/Egln1^tm2.1Fsl Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺	B6.Cg-Egln1^tm2.1Fsl Commd10^{Tg(Vav1-icre)A2Kio}	MGI:5525143
cn2	Egln1^tm2.1Fsl/Egln1^tm2.1Fsl Tg(Cdh5-cre)7Mlia/0	B6.Cg-Egln1^tm2.1Fsl Tg(Cdh5-cre)7Mlia	MGI:5525142
cn3	Egln1^tm2.1Fsl/Egln1^tm2.1Fsl Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺	B6.Cg-Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} Egln1^tm2.1Fsl	MGI:5525144
cn4	Egln1^tm2.1Fsl/Egln1^tm2.1Fsl Epas1^tm1Mcs/Epas1^tm1Mcs Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺	B6.Cg-Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} Egln1^tm2.1Fsl Epas1^tm1Mcs	MGI:5525147
cn5	Egln1^tm2.1Fsl/Egln1^tm2.1Fsl Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ Hif1a^tm3Rsjo/Hif1a^tm3Rsjo	B6.Cg-Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} Egln1^tm2.1Fsl Hif1a^tm3Rsjo	MGI:5525146
cn6	Egln1^tm2.1Fsl/Egln1⁺ Pax3^tm1(cre)Joe/Pax3⁺	involves: 129 * C57BL/6	MGI:5525141
cn7	Egln1^tm2.1Fsl/Egln1^tm2.1Fsl Pax3^tm1(cre)Joe/Pax3⁺	involves: 129 * C57BL/6	MGI:5525140

Allelic Composition	Egln1^tm2.1Fsl/Egln1^tm2.1Fsl Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
Genetic Background	B6.Cg-Egln1^tm2.1Fsl Commd10^{Tg(Vav1-icre)A2Kio}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10^{Tg(Vav1-icre)A2Kio} mutation (3 available); any Commd10 mutation (24 available)
Egln1^tm2.1Fsl mutation (0 available); any Egln1 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased erythroid progenitor cell number ( J:202737 )

• increased numbers of BFU-E colonies are observed at both high and low concentrations of erythropoietin

polycythemia ( J:202737 )

• mice exhibit erythrocytosis, however, erythropoietin levels are not increased

increased hematocrit ( J:202737 )

• hematocrits are modestly increased over controls

increased hemoglobin content ( J:202737 )

Allelic Composition	Egln1^tm2.1Fsl/Egln1^tm2.1Fsl Tg(Cdh5-cre)7Mlia/0
Genetic Background	B6.Cg-Egln1^tm2.1Fsl Tg(Cdh5-cre)7Mlia

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1^tm2.1Fsl mutation (0 available); any Egln1 mutation (22 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased heart weight ( J:202737 )

• increased cardiac mass as compared to controls

mortality/aging

premature death ( J:202737 )

• less than half of mice survive to 6 months of age

growth/size/body

increased heart weight ( J:202737 )

• increased cardiac mass as compared to controls

Allelic Composition	Egln1^tm2.1Fsl/Egln1^tm2.1Fsl Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺
Genetic Background	B6.Cg-Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} Egln1^tm2.1Fsl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1^tm2.1Fsl mutation (0 available); any Egln1 mutation (22 available)
Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} mutation (2 available); any Gt(ROSA)26Sor mutation (991 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased spleen weight ( J:202737 )

• following treatment with tamoxifen

extramedullary hematopoiesis ( J:202737 )

• following treatment with tamoxifen, extramedullary hematopoiesis is observed in spleens

polycythemia ( J:202737 )

• following treatment with tamoxifen, mice exhibit erythrocytosis

increased hematocrit ( J:202737 )

• following treatment with tamoxifen, mice exhibit hematocrits close to 80%

homeostasis/metabolism

increased erythropoietin level ( J:202737 )

• following treatment with tamoxifen, mice exhibit increased serum erythropoietin levels

immune system

increased spleen weight ( J:202737 )

• following treatment with tamoxifen

mortality/aging

premature death ( J:202737 )

• following treatment with tamoxifen

growth/size/body

increased spleen weight ( J:202737 )

• following treatment with tamoxifen

Allelic Composition	Egln1^tm2.1Fsl/Egln1^tm2.1Fsl Epas1^tm1Mcs/Epas1^tm1Mcs Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺
Genetic Background	B6.Cg-Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} Egln1^tm2.1Fsl Epas1^tm1Mcs

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1^tm2.1Fsl mutation (0 available); any Egln1 mutation (22 available)
Epas1^tm1Mcs mutation (1 available); any Epas1 mutation (66 available)
Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} mutation (2 available); any Gt(ROSA)26Sor mutation (991 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:202737 )

N	• hematocrit level, erythropoietin level and spleen architecture and weight are similar to mice without cre/ESR1 allele • the Epas1 allele functions to rescue the erythrocytosis phenotype

mortality/aging

premature death ( J:202737 )

• survival is improved relative to mice carrying the Egln1 null allele, but not to control levels

Allelic Composition	Egln1^tm2.1Fsl/Egln1^tm2.1Fsl Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ Hif1a^tm3Rsjo/Hif1a^tm3Rsjo
Genetic Background	B6.Cg-Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} Egln1^tm2.1Fsl Hif1a^tm3Rsjo

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased spleen weight ( J:202737 )

• following treatment with tamoxifen

extramedullary hematopoiesis ( J:202737 )

• following treatment with tamoxifen, extramedullary hematopoiesis is observed in spleens

increased hematocrit ( J:202737 )

• following treatment with tamoxifen, mice exhibit hematocrits close to 80%

homeostasis/metabolism

increased erythropoietin level ( J:202737 )

• following treatment with tamoxifen, mice exhibit increased serum erythropoietin levels

immune system

increased spleen weight ( J:202737 )

• following treatment with tamoxifen

mortality/aging

premature death ( J:202737 )

• following treatment with tamoxifen, however, survival is improved relative to tamoxifen treated Egln1^tm2.1Fsl mice alone

growth/size/body

increased spleen weight ( J:202737 )

• following treatment with tamoxifen

Allelic Composition	Egln1^tm2.1Fsl/Egln1⁺ Pax3^tm1(cre)Joe/Pax3⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1^tm2.1Fsl mutation (0 available); any Egln1 mutation (22 available)
Pax3^tm1(cre)Joe mutation (1 available); any Pax3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

polycythemia ( J:202737 )

• mice exhibit erythrocytosis, however, erythropoietin levels are not increased

increased hematocrit ( J:202737 )

• hematocrits are modestly (60%) increased over controls

Allelic Composition	Egln1^tm2.1Fsl/Egln1^tm2.1Fsl Pax3^tm1(cre)Joe/Pax3⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal liver vasculature morphology ( J:202737 )

• number and size of vessels is increased as compared to controls

increased heart weight ( J:202737 )

• increased cardiac mass as compared to controls

hematopoietic system

increased spleen weight ( J:202737 )

polycythemia ( J:202737 )

• mice exhibit erythrocytosis, however, erythropoietin levels are not increased

increased hematocrit ( J:202737 )

• mice exhibit hematocrits of over 80%

immune system

increased spleen weight ( J:202737 )

liver/biliary system

abnormal liver vasculature morphology ( J:202737 )

• number and size of vessels is increased as compared to controls

increased liver weight ( J:202737 )

growth/size/body

increased heart weight ( J:202737 )

• increased cardiac mass as compared to controls

increased liver weight ( J:202737 )

increased spleen weight ( J:202737 )

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