Phenotypes associated with this allele

• Allele Symbol: Egln1^tm2.2Fsl
• Allele Name: targeted mutation 2.2, Frank Lee
• Allele ID: MGI:5521471
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Egln1^tm2.2Fsl/Egln1^tm2.2Fsl	B6.Cg-Egln1^tm2.2Fsl	MGI:5525149
ht2	Egln1^tm2.2Fsl/Egln1^+	B6.Cg-Egln1^tm2.2Fsl	MGI:5525148

Genotype
MGI:5525149

hm1

• Allelic Composition: Egln1^tm2.2Fsl/Egln1^tm2.2Fsl
• Genetic Background: B6.Cg-Egln1^tm2.2Fsl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:202737 )

• heterozygote x heterozygote crosses fail to produce homozygous progeny

Genotype
MGI:5525148

ht2

• Allelic Composition: Egln1^tm2.2Fsl/Egln1⁺
• Genetic Background: B6.Cg-Egln1^tm2.2Fsl

hematopoietic system

increased spleen weight ( J:202737 )

• spleen weight is slightly increased as compared to wild-type

polycythemia ( J:202737 )

• mice exhibit erythrocytosis, however, erythropoietin levels are not increased

increased hematocrit ( J:202737 )

increased hemoglobin content ( J:202737 )

immune system

increased spleen weight ( J:202737 )

• spleen weight is slightly increased as compared to wild-type

respiratory system

increased pulmonary ventilation ( J:202737 )

growth/size/body

increased spleen weight ( J:202737 )

• spleen weight is slightly increased as compared to wild-type