homeostasis/metabolism
|
• mice exhibit normal respiratory exchange ratio and core body temperature
|
|
• more than 20-fold
|
|
• in fasting mice at 30 weeks
|
|
• in fasting mice at 30 weeks
|
|
• total and non-HDL
|
|
• non-esterified
|
|
• more than 4-fold
|
|
• relative to weight
|
|
• at 30 weeks
|
|
• more than 30-fold
|
|
• at 30 weeks
|
liver/biliary system
|
• perisinusoidal/sinusoidal foam cells
|
|
• 5-fold increase in weight for non-emptied gall bladder
|
|
• at 30 weeks
|
|
• at 30 weeks
|
|
• perisinusoidal/sinusoidal foam cells
|
|
• non-alcoholic steatohepatitis
|
|
• ballooning
|
|
• lobular, non-alcoholic steatohepatitis
|
adipose tissue
|
• at 30 weeks
|
|
• with reduced density
|
growth/size/body
|
• mice exhibit normal lean mass
|
|
• 5-fold increase in weight for non-emptied gall bladder
|
|
• at 21 and 39 weeks
|
|
• at 30 weeks
|
skeleton
|
• at 30 weeks
|
|
• slightly at 9 weeks
• at 30 weeks
|
behavior/neurological
|
• relative to weight at 29 to 31 weeks
|
|
• increased energy intake relative to weight at 29 to 31 weeks
• however, relative total energy uptake is normal
|
immune system
|
• lobular, non-alcoholic steatohepatitis
|
endocrine/exocrine glands
|
• 5-fold increase in weight for non-emptied gall bladder
|
digestive/alimentary system
integument
|
• mice exhibit normal skin morphology
|
hematopoietic system
cardiovascular system
|
• perisinusoidal/sinusoidal foam cells
|