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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sdhbtm1.1Ics
targeted mutation 1.1, Mouse Clinical Institute
MGI:5521531
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ptentm1Mro/Ptentm1Mro
Sdhbtm1.1Ics/Sdhbtm1.2Ics
Tg(KLK3-cre)D4Trp/0 		involves: 129S2/SvPas * BALB/c * C57BL/6 * FVB MGI:5812678
cn2
 		Sdhbtm1.1Ics/Sdhbtm1.1Ics
Tg(Th-cre)12Mrub/0 		involves: 129S2/SvPas * C57BL/6 * CBA MGI:5812672
cn3
 		Sdhbtm1.1Ics/Sdhbtm1.1Ics
Tg(KLK3-cre)D4Trp/0 		involves: 129S2/SvPas * FVB MGI:5812673
cn4
 		Ptentm1Mro/Ptentm1Mro
Sdhbtm1.1Ics/Sdhb+
Tg(KLK3-cre)D4Trp/0 		involves: 129S2/SvPas * FVB MGI:5812676
cn5
 		Ptentm1Mro/Pten+
Sdhbtm1.1Ics/Sdhb+
Tg(KLK3-cre)D4Trp/0 		involves: 129S2/SvPas * FVB MGI:5812679


Genotype
MGI:5812678
cn1
Allelic
Composition		 Ptentm1Mro/Ptentm1Mro
Sdhbtm1.1Ics/Sdhbtm1.2Ics
Tg(KLK3-cre)D4Trp/0
Genetic
Background		 involves: 129S2/SvPas * BALB/c * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Mro mutation (1 available); any Pten mutation (88 available)
Sdhbtm1.1Ics mutation (0 available); any Sdhb mutation (29 available)
Sdhbtm1.2Ics mutation (0 available); any Sdhb mutation (29 available)
Tg(KLK3-cre)D4Trp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased pheochromocytoma incidence ( J:236514 )
• 42% incidence of pheochromocytoma
• tumors do not show accumulation of succinate

neoplasm
increased pheochromocytoma incidence ( J:236514 )
• 42% incidence of pheochromocytoma
• tumors do not show accumulation of succinate




Genotype
MGI:5812672
cn2
Allelic
Composition		 Sdhbtm1.1Ics/Sdhbtm1.1Ics
Tg(Th-cre)12Mrub/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdhbtm1.1Ics mutation (0 available); any Sdhb mutation (29 available)
Tg(Th-cre)12Mrub mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:236514 )
• mice are viable, fertile and have no apparent phenotype




Genotype
MGI:5812673
cn3
Allelic
Composition		 Sdhbtm1.1Ics/Sdhbtm1.1Ics
Tg(KLK3-cre)D4Trp/0
Genetic
Background		 involves: 129S2/SvPas * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdhbtm1.1Ics mutation (0 available); any Sdhb mutation (29 available)
Tg(KLK3-cre)D4Trp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:236514 )
• mice are viable, fertile and have no apparent phenotype




Genotype
MGI:5812676
cn4
Allelic
Composition		 Ptentm1Mro/Ptentm1Mro
Sdhbtm1.1Ics/Sdhb+
Tg(KLK3-cre)D4Trp/0
Genetic
Background		 involves: 129S2/SvPas * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Mro mutation (1 available); any Pten mutation (88 available)
Sdhbtm1.1Ics mutation (0 available); any Sdhb mutation (29 available)
Tg(KLK3-cre)D4Trp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased pheochromocytoma incidence ( J:236514 )
• 89% of mice show pheochromocytoma at 12.9 months of age
• tumors do not show accumulation of succinate

neoplasm
increased pheochromocytoma incidence ( J:236514 )
• 89% of mice show pheochromocytoma at 12.9 months of age
• tumors do not show accumulation of succinate

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
pheochromocytoma DOID:0050771 OMIM:171300
 J:236514




Genotype
MGI:5812679
cn5
Allelic
Composition		 Ptentm1Mro/Pten+
Sdhbtm1.1Ics/Sdhb+
Tg(KLK3-cre)D4Trp/0
Genetic
Background		 involves: 129S2/SvPas * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Mro mutation (1 available); any Pten mutation (88 available)
Sdhbtm1.1Ics mutation (0 available); any Sdhb mutation (29 available)
Tg(KLK3-cre)D4Trp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased pheochromocytoma incidence ( J:236514 )
• 64% of mice develop pheochromocytoma

neoplasm
increased pheochromocytoma incidence ( J:236514 )
• 64% of mice develop pheochromocytoma




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory