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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sdhbtm1.2Ics
targeted mutation 1.2, Mouse Clinical Institute
MGI:5521532
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sdhbtm1.2Ics/Sdhbtm1.2Ics involves: 129S2/SvPas * BALB/c * C57BL/6 MGI:5812671
cn2
 		Ptentm1Mro/Ptentm1Mro
Sdhbtm1.1Ics/Sdhbtm1.2Ics
Tg(KLK3-cre)D4Trp/0 		involves: 129S2/SvPas * BALB/c * C57BL/6 * FVB MGI:5812678
cx3
 		Ptentm1.1Mro/Pten+
Sdhbtm1.2Ics/Sdhb+ 		involves: 129S2/SvPas * BALB/c * C57BL/6 MGI:5812674


Genotype
MGI:5812671
hm1
Allelic
Composition		 Sdhbtm1.2Ics/Sdhbtm1.2Ics
Genetic
Background		 involves: 129S2/SvPas * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdhbtm1.2Ics mutation (0 available); any Sdhb mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:236514 )
• embryonic lethality before E7.5




Genotype
MGI:5812678
cn2
Allelic
Composition		 Ptentm1Mro/Ptentm1Mro
Sdhbtm1.1Ics/Sdhbtm1.2Ics
Tg(KLK3-cre)D4Trp/0
Genetic
Background		 involves: 129S2/SvPas * BALB/c * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Mro mutation (1 available); any Pten mutation (88 available)
Sdhbtm1.1Ics mutation (0 available); any Sdhb mutation (29 available)
Sdhbtm1.2Ics mutation (0 available); any Sdhb mutation (29 available)
Tg(KLK3-cre)D4Trp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased pheochromocytoma incidence ( J:236514 )
• 42% incidence of pheochromocytoma
• tumors do not show accumulation of succinate

neoplasm
increased pheochromocytoma incidence ( J:236514 )
• 42% incidence of pheochromocytoma
• tumors do not show accumulation of succinate




Genotype
MGI:5812674
cx3
Allelic
Composition		 Ptentm1.1Mro/Pten+
Sdhbtm1.2Ics/Sdhb+
Genetic
Background		 involves: 129S2/SvPas * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1.1Mro mutation (0 available); any Pten mutation (88 available)
Sdhbtm1.2Ics mutation (0 available); any Sdhb mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased pheochromocytoma incidence ( J:236514 )
• at 10 months of age, 80% of mice develop a pheochromocytoma

neoplasm
increased pheochromocytoma incidence ( J:236514 )
• at 10 months of age, 80% of mice develop a pheochromocytoma
increased metastatic potential ( J:236514 )
• lung micro-metastasis are seen in 73% of mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory