About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sdhbtm1.2Ics
targeted mutation 1.2, Mouse Clinical Institute
MGI:5521532
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sdhbtm1.2Ics/Sdhbtm1.2Ics involves: 129S2/SvPas * BALB/c * C57BL/6 MGI:5812671
cn2
 		Ptentm1Mro/Ptentm1Mro
Sdhbtm1.1Ics/Sdhbtm1.2Ics
Tg(KLK3-cre)D4Trp/0 		involves: 129S2/SvPas * BALB/c * C57BL/6 * FVB MGI:5812678
cx3
 		Ptentm1.1Mro/Pten+
Sdhbtm1.2Ics/Sdhb+ 		involves: 129S2/SvPas * BALB/c * C57BL/6 MGI:5812674


Genotype
MGI:5812671
hm1
Allelic
Composition		 Sdhbtm1.2Ics/Sdhbtm1.2Ics
Genetic
Background		 involves: 129S2/SvPas * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdhbtm1.2Ics mutation (0 available); any Sdhb mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:236514 )
• embryonic lethality before E7.5




Genotype
MGI:5812678
cn2
Allelic
Composition		 Ptentm1Mro/Ptentm1Mro
Sdhbtm1.1Ics/Sdhbtm1.2Ics
Tg(KLK3-cre)D4Trp/0
Genetic
Background		 involves: 129S2/SvPas * BALB/c * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Mro mutation (1 available); any Pten mutation (88 available)
Sdhbtm1.1Ics mutation (0 available); any Sdhb mutation (29 available)
Sdhbtm1.2Ics mutation (0 available); any Sdhb mutation (29 available)
Tg(KLK3-cre)D4Trp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased pheochromocytoma incidence ( J:236514 )
• 42% incidence of pheochromocytoma
• tumors do not show accumulation of succinate

neoplasm
increased pheochromocytoma incidence ( J:236514 )
• 42% incidence of pheochromocytoma
• tumors do not show accumulation of succinate




Genotype
MGI:5812674
cx3
Allelic
Composition		 Ptentm1.1Mro/Pten+
Sdhbtm1.2Ics/Sdhb+
Genetic
Background		 involves: 129S2/SvPas * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1.1Mro mutation (0 available); any Pten mutation (88 available)
Sdhbtm1.2Ics mutation (0 available); any Sdhb mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased pheochromocytoma incidence ( J:236514 )
• at 10 months of age, 80% of mice develop a pheochromocytoma

neoplasm
increased pheochromocytoma incidence ( J:236514 )
• at 10 months of age, 80% of mice develop a pheochromocytoma
increased metastatic potential ( J:236514 )
• lung micro-metastasis are seen in 73% of mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory