Analysis Tools|
Allele Symbol Allele Name Allele ID |
Chek2tm1b(EUCOMM)Hmgu targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH MGI:5521536 |
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| Summary |
2 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• although there are fewer than normal metaphase oocytes with normal chiasmata between homologous chromosomes, there is a 25% increase compared to mice with wild-type CHEK2
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• P0 oocytes show asynapsis, but to a much less degree than in the presence of CHEK2 and a comparative 3 fold increase in dictyate oocytes
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• although there are fewer than normal metaphase oocytes with normal chiasmata between homologous chromosomes, there is a 25% increase compared to mice with wild-type CHEK2
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• P0 oocytes show asynapsis, but to a much less degree than in the presence of CHEK2 and a comparative 3 fold increase in dictyate oocytes
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• although there is reduced fertility compared with C57BL/6J controls, compared with Prdm9 null mice wild-type for CHEK2 these double null females produce at least 1 litter in 6 months so have comparatively increased fertility, yet have a high rate of spontaneous abortion and perinatal deaths in pups.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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