Phenotypes associated with this allele

• Allele Symbol: H2-Ab1^b-tm1.1Jssh
• Allele Name: targeted mutation 1.1, Jeoung-Sook Shin
• Allele ID: MGI:5521551
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H2-Ab1^b-tm1.1Jssh/H2-Ab1^b-tm1.1Jssh	C57BL/6-H2-Ab1^b-tm1.1Jssh	MGI:5521552

Genotype
MGI:5521552

hm1

• Allelic Composition: H2-Ab1^b-tm1.1Jssh/H2-Ab1^b-tm1.1Jssh
• Genetic Background: C57BL/6-H2-Ab1^b-tm1.1Jssh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:201198 )

• dendritic cell-intrinsic reduction in regulatory T cell development from bone marrow cells transplanted into irradiated host mice

• however, deletion of blood-borne, antigen-specific CD4 single positive thymocytes is normal

decreased regulatory T cell number ( J:201198 )

abnormal dendritic cell antigen presentation ( J:201198 )

• increased

hematopoietic system

abnormal T cell differentiation ( J:201198 )

• dendritic cell-intrinsic reduction in regulatory T cell development from bone marrow cells transplanted into irradiated host mice

• however, deletion of blood-borne, antigen-specific CD4 single positive thymocytes is normal

decreased regulatory T cell number ( J:201198 )