Phenotypes associated with this allele

• Allele Symbol: Vapb^tm1.2Ics
• Allele Name: targeted mutation 1.2, Mouse Clinical Institute
• Allele ID: MGI:5521564
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vapb^tm1.2Ics/Vapb^tm1.2Ics	B6N.129S2-Vapb^tm1.2Ics	MGI:5521569

Genotype
MGI:5521569

hm1

• Allelic Composition: Vapb^tm1.2Ics/Vapb^tm1.2Ics
• Genetic Background: B6N.129S2-Vapb^tm1.2Ics

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tremors ( J:198145 )

• mild in an open field

impaired coordination ( J:198145 )

• at 18, but not 4, months

muscle

hypotonia ( J:198145 )

• in the hind limb and abdomen of older mice

• however, muscle strength in a grip test is normal

nervous system

nervous system phenotype ( J:198145 )

N • mice exhibit normal neuromuscular junctions with no denervation

cellular

cellular phenotype ( J:198145 )

N • mice exhibit normal basal and tunicamycin-induce unfolded protein response