Phenotypes associated with this allele

• Allele Symbol: Bcl11b^m1Jpk
• Allele Name: mutation 1, Japan Kominami
• Allele ID: MGI:5522760
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Bcl11b^m1Jpk/Bcl11b^tm1Jpk	involves: BALB/c * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	MGI:5522772

Genotype
MGI:5522772

ht1

• Allelic Composition: Bcl11b^m1Jpk/Bcl11b^tm1Jpk
• Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality at weaning, complete penetrance ( J:199312 )

• due to difficulty taking food

• however, survival is improved by cutting incisors and providing small-sized food materials

craniofacial

short basicranium ( J:199312 )

• short anterior cranial base

abnormal incisor morphology ( J:199312 )

• lower calcium and phosphorus concentrations in incisor enamel and dentin

• lower iron deposition in the incisors enamel

long incisors ( J:199312 )

abnormal tooth development ( J:199312 )

• maxillary incisor hyperplasia

• shortening of the immature odondoblast region at P21

• reduced number of proliferating ameloblast and odontoblast cells in incisors without a change in apoptosis rates

• fewer label retaining cells (indicating stem cells) in incisors with normal distribution

• however, postnatal incisor formation occurs

abnormal ameloblast morphology ( J:199312 )

• reduced number of proliferating cells in incisors

short maxilla ( J:199312 )

midface hypoplasia ( J:199312 )

growth/size/body

abnormal incisor morphology ( J:199312 )

• lower calcium and phosphorus concentrations in incisor enamel and dentin

• lower iron deposition in the incisors enamel

long incisors ( J:199312 )

abnormal tooth development ( J:199312 )

• maxillary incisor hyperplasia

• shortening of the immature odondoblast region at P21

• reduced number of proliferating ameloblast and odontoblast cells in incisors without a change in apoptosis rates

• fewer label retaining cells (indicating stem cells) in incisors with normal distribution

• however, postnatal incisor formation occurs

abnormal ameloblast morphology ( J:199312 )

• reduced number of proliferating cells in incisors

midface hypoplasia ( J:199312 )

decreased birth body size ( J:199312 )

decreased birth weight ( J:199312 )

skeleton

short basicranium ( J:199312 )

• short anterior cranial base

abnormal incisor morphology ( J:199312 )

• lower calcium and phosphorus concentrations in incisor enamel and dentin

• lower iron deposition in the incisors enamel

long incisors ( J:199312 )

abnormal tooth development ( J:199312 )

• maxillary incisor hyperplasia

• shortening of the immature odondoblast region at P21

• reduced number of proliferating ameloblast and odontoblast cells in incisors without a change in apoptosis rates

• fewer label retaining cells (indicating stem cells) in incisors with normal distribution

• however, postnatal incisor formation occurs

abnormal ameloblast morphology ( J:199312 )

• reduced number of proliferating cells in incisors

short maxilla ( J:199312 )