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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trpm2tm1Lhj
targeted mutation 1, Lin-Hua Jiang
MGI:5522800
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trpm2tm1Lhj/Trpm2tm1Lhj Not Specified MGI:5522832


Genotype
MGI:5522832
hm1
Allelic
Composition		 Trpm2tm1Lhj/Trpm2tm1Lhj
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpm2tm1Lhj mutation (0 available); any Trpm2 mutation (112 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal macrophage morphology ( J:202791 )
• macrophages treated with hydrogen peroxide fail to exhibit an increase in extracellular calcium unlike wild-type cells
abnormal macrophage physiology ( J:202791 )
• hydrogen peroxide-treated macrophages exhibit a decrease in the reduction of cell viability compared with wild-type cells

immune system
abnormal macrophage morphology ( J:202791 )
• macrophages treated with hydrogen peroxide fail to exhibit an increase in extracellular calcium unlike wild-type cells
abnormal macrophage physiology ( J:202791 )
• hydrogen peroxide-treated macrophages exhibit a decrease in the reduction of cell viability compared with wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory