Phenotypes associated with this allele

• Allele Symbol: Hoxd^tm1.1Ssp
• Allele Name: targeted mutation 1.1, S Steven Potter
• Allele ID: MGI:5522949
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxd^tm1.1Ssp/Hoxd^tm1.1Ssp	involves: 129 * CD-1	MGI:5522969
cx2	Hoxa^tm1.1Ssp/Hoxa^tm1.1Ssp Hoxd^tm1.1Ssp/Hoxd^+	involves: 129 * CD-1	MGI:5522980
cx3	Hoxa^tm1.1Ssp/Hoxa^+ Hoxd^tm1.1Ssp/Hoxd^tm1.1Ssp	involves: 129 * CD-1	MGI:5522979
cx4	Hoxa^tm1.1Ssp/Hoxa^tm1.1Ssp Hoxd^tm1.1Ssp/Hoxd^tm1.1Ssp	involves: 129 * CD-1	MGI:5522972
cx5	Hoxa^tm1.1Ssp/Hoxa^+ Hoxd^tm1.1Ssp/Hoxd^+	involves: 129 * CD-1	MGI:5522978

Genotype
MGI:5522969

hm1

• Allelic Composition: Hoxd^tm1.1Ssp/Hoxd^tm1.1Ssp
• Genetic Background: involves: 129 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:198638 )

♀N • no gross uterine abnormalities are detected

abnormal vas deferens morphology ( J:198638 )

♂ • occasional minor coiling near the epididymal junction

reduced female fertility ( J:198638 )

♀ • show evidence of subfertility

♀ • pups in litters born to homozygous females often die postnatally with no milk spot or are severely runted

decreased litter size ( J:198638 )

♀ • seen when mutant females when mated to wild-type males

♀ • pups in litters born to homozygous females often die postnatally with no milk spot or are severely runted

male infertility ( J:198638 )

♂ • males fail to produce vaginal plugs when mated with wild-type females

behavior/neurological

failure of copulatory plug deposition ( J:198638 )

♂ • males fail to produce vaginal plugs when mated with wild-type females

Genotype
MGI:5522980

cx2

• Allelic Composition: Hoxa^tm1.1Ssp/Hoxa^tm1.1Ssp; Hoxd^tm1.1Ssp/Hoxd⁺
• Genetic Background: involves: 129 * CD-1

reproductive system

abnormal uterus morphology ( J:198638 )

♀ • anteriorization of the uterus is exacerbated compared to mice homozygous for the Hoxa mutation alone

♀ • coiled for nearly half the length

♀ • uteri closely resemble oviducts

♀ • reduction of the stromal layer and an increase in luminal branching

thin myometrium ( J:198638 )

♀

thin uterus ( J:198638 )

♀ • extremely thin

abnormal cauda epididymis morphology ( J:198638 )

♂ • smaller tubules which resemble those in the more anterior caput

♂ • smaller with an extremely thin muscle layer, thinning is more severe than in mice homozygous for the Hoxa mutation alone

small epididymis ( J:198638 )

♂ • smaller caudal epididymis

abnormal vas deferens morphology ( J:198638 )

♂ • significant enhancement of the anteriorization compared to mice homozygous for the Hoxa mutation alone

♂ • extreme coiling from the epididymal junction extending posterior for approximately one-third of the length

♂ • resembles the wild-type caudal epididymis with thinner muscle and stromal layers

female infertility ( J:198638 )

♀

male infertility ( J:198638 )

♂

Genotype
MGI:5522979

cx3

• Allelic Composition: Hoxa^tm1.1Ssp/Hoxa⁺; Hoxd^tm1.1Ssp/Hoxd^tm1.1Ssp
• Genetic Background: involves: 129 * CD-1

reproductive system

abnormal testis morphology ( J:198638 )

♂ • canalicular testes located just above the scrotum are more commonly seen

unilateral cryptorchism ( J:198638 )

♂ • unilateral cryptorchidism is rarely seen

abnormal uterus morphology ( J:198638 )

♀ • slight coiling at the anterior end

♀ • reduction of the stromal layer and an increase in luminal branching

thin myometrium ( J:198638 )

♀

thin uterus ( J:198638 )

♀

abnormal cauda epididymis morphology ( J:198638 )

♂ • smaller with a thinner muscle layer

♂ • resembles the more anterior caput segment

small epididymis ( J:198638 )

♂ • smaller caudal epididymis

abnormal vas deferens morphology ( J:198638 )

♂ • typically display coiling of the proximal end

♂ • reduced muscle layer, particularly in the anterior portion

female infertility ( J:198638 )

♀

endocrine/exocrine glands

abnormal testis morphology ( J:198638 )

♂ • canalicular testes located just above the scrotum are more commonly seen

unilateral cryptorchism ( J:198638 )

♂ • unilateral cryptorchidism is rarely seen

Genotype
MGI:5522972

cx4

• Allelic Composition: Hoxa^tm1.1Ssp/Hoxa^tm1.1Ssp; Hoxd^tm1.1Ssp/Hoxd^tm1.1Ssp
• Genetic Background: involves: 129 * CD-1

mortality/aging

neonatal lethality, complete penetrance ( J:198638 )

• all die shortly after birth

Genotype
MGI:5522978

cx5

• Allelic Composition: Hoxa^tm1.1Ssp/Hoxa⁺; Hoxd^tm1.1Ssp/Hoxd⁺
• Genetic Background: involves: 129 * CD-1

reproductive system

abnormal internal female genitalia morphology ( J:198638 )

♀ • often display an elongated uterotubal junction

abnormal vas deferens morphology ( J:198638 )

♂ • show some gross coiling of the anterior vas deferens

female infertility ( J:198638 )

♀ • about 26% of females with a vaginal plug fail to produce pups

reduced female fertility ( J:198638 )

♀ • females that do become pregnant have smaller litters

decreased litter size ( J:198638 )

♀