About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Porcntm1.1Jrt
targeted mutation 1.1, Janet Rossant
MGI:5523157
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Porcntm1.1Jrt/Porcn+ B6.Cg-Porcntm1.1Jrt MGI:5523420
ht2
 		Porcntm1.1Jrt/Porcn+ involves: 129S6/SvEvTac * C57BL/6NCr * ICR MGI:5523424
cn3
 		Porcntm1.1Jrt/Porcn+
Tg(CAG-EGFP)D4Nagy/0
Tg(Zp3-cre)3Mrt/0 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCr * FVB/N MGI:5523431
cn4
 		Porcntm1.1Jrt/Y
Tg(CAG-EGFP)D4Nagy/0
Tg(Zp3-cre)3Mrt/0 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCr * FVB/N MGI:5523432
cn5
 		Porcntm1.1Jrt/Porcn+
Tg(Ttr-cre)1Hadj/0 		involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * CBA/J MGI:5523430
cn6
 		Porcntm1.1Jrt/Porcn+
Tg(CAG-cre)1Nagy/0 		involves: 129S6/SvEvTac * C57BL/6NCr * ICR MGI:5523429
cn7
 		Porcntm1.1Jrt/Y
Tg(CAG-cre)1Nagy/0 		involves: 129S6/SvEvTac * C57BL/6NCr * ICR MGI:5523428
ot8
 		Porcntm1.1Jrt/Y B6.Cg-Porcntm1.1Jrt MGI:5523417
ot9
 		Porcntm1.1Jrt/Y involves: 129S6/SvEvTac * C57BL/6NCr * ICR MGI:5523422


Genotype
MGI:5523420
ht1
Allelic
Composition		 Porcntm1.1Jrt/Porcn+
Genetic
Background		 B6.Cg-Porcntm1.1Jrt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcntm1.1Jrt mutation (1 available); any Porcn mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:198636 )
• no defects observed
• fertility normal




Genotype
MGI:5523424
ht2
Allelic
Composition		 Porcntm1.1Jrt/Porcn+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCr * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcntm1.1Jrt mutation (1 available); any Porcn mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:198636 )
• no defects observed
• fertility normal




Genotype
MGI:5523431
cn3
Allelic
Composition		 Porcntm1.1Jrt/Porcn+
Tg(CAG-EGFP)D4Nagy/0
Tg(Zp3-cre)3Mrt/0
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCr * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcntm1.1Jrt mutation (1 available); any Porcn mutation (18 available)
Tg(CAG-EGFP)D4Nagy mutation (2 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:198636 )
N
• heterozygous females implant normally when the mutant allele ant the cre transgene are from the mother and the reporter is from the father




Genotype
MGI:5523432
cn4
Allelic
Composition		 Porcntm1.1Jrt/Y
Tg(CAG-EGFP)D4Nagy/0
Tg(Zp3-cre)3Mrt/0
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCr * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcntm1.1Jrt mutation (1 available); any Porcn mutation (18 available)
Tg(CAG-EGFP)D4Nagy mutation (2 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
failure to gastrulate ( J:198636 )
• hemizygous males fail to gastrulate when mutant and cre are derived from the mother and the reporter is derived from the father




Genotype
MGI:5523430
cn5
Allelic
Composition		 Porcntm1.1Jrt/Porcn+
Tg(Ttr-cre)1Hadj/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcntm1.1Jrt mutation (1 available); any Porcn mutation (18 available)
Tg(Ttr-cre)1Hadj mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:198636 )
N
• heterozygous females present at the expected ratio at weaning




Genotype
MGI:5523429
cn6
Allelic
Composition		 Porcntm1.1Jrt/Porcn+
Tg(CAG-cre)1Nagy/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCr * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcntm1.1Jrt mutation (1 available); any Porcn mutation (18 available)
Tg(CAG-cre)1Nagy mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:198636 )
• embryos in which the mutant allele is derived from the mother are only recovered to E11.5

embryo
embryo phenotype ( J:198636 )
N
• chorionic plate is normal in E9.5 embryos in which the mutant allele is derived from the mother
abnormal embryo development ( J:198636 )
• embryos described above fail to thrive
abnormal allantois morphology ( J:198636 )
• a ball of allantoic tissue is found at the posterior end of the embryos described above
abnormal placenta morphology ( J:198636 )
• embryos described above fail to establish a functional placenta
abnormal umbilical cord morphology ( J:198636 )
• embryos descrbed above fail to establish a functional umbilical cord

nervous system
nervous system phenotype ( J:198636 )
N
• neural tube closure defects are very rare




Genotype
MGI:5523428
cn7
Allelic
Composition		 Porcntm1.1Jrt/Y
Tg(CAG-cre)1Nagy/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCr * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcntm1.1Jrt mutation (1 available); any Porcn mutation (18 available)
Tg(CAG-cre)1Nagy mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo

growth/size/body
decreased embryo size ( J:198636 )




Genotype
MGI:5523417
ot8
Allelic
Composition		 Porcntm1.1Jrt/Y
Genetic
Background		 B6.Cg-Porcntm1.1Jrt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcntm1.1Jrt mutation (1 available); any Porcn mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:198636 )
• no defects observed
• fertility normal




Genotype
MGI:5523422
ot9
Allelic
Composition		 Porcntm1.1Jrt/Y
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCr * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcntm1.1Jrt mutation (1 available); any Porcn mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:198636 )
• no defects observed
• fertility normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory