Phenotypes associated with this allele

• Allele Symbol: Nr2f1^tm2.1Mist
• Allele Name: targeted mutation 2.1, Michele Studer
• Allele ID: MGI:5523158
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr2f1^tm2.1Mist/Nr2f1^tm2.1Mist	involves: 129S2/SvPas * C57BL/6J	MGI:5523192
cn2	Nr2f1^tm2.1Mist/Nr2f1^tm2.1Mist Emx1^tm1(cre)Krj/Emx1^+	involves: 129S2/SvPas * C57BL/6J	MGI:5523193

Genotype
MGI:5523192

hm1

• Allelic Composition: Nr2f1^tm2.1Mist/Nr2f1^tm2.1Mist
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:127387 )

• mice are viable and fertile

Genotype
MGI:5523193

cn2

• Allelic Composition: Nr2f1^tm2.1Mist/Nr2f1^tm2.1Mist; Emx1^tm1(cre)Krj/Emx1⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

nervous system

nervous system phenotype ( J:127387 )

N • subplate cells differentiate normally

abnormal cerebral cortex morphology ( J:127387 )

• altered thalamocortical targeting

• massively expanded frontal areas, including motor

• altered areal output projections

• projection neurons in the parietal cortex adopt the identity of motor area-projection neurons rather than S1 identity

abnormal primary somatosensory cortex morphology ( J:127387 )

• the primary sensory areas (A1, S1 and V1) are reduced in size and positioned far caudally in the cortical hemisphere compared with wild-type mice

• primary sensory areas coarsely maintain their positions relative to one another along the mediolateral cortical axis but not the rostrocaudal axis

abnormal barrel cortex morphology ( J:127387 )

• reduced size and ectopically located