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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pappatm1Lex
targeted mutation 1, Lexicon Genomics
MGI:5523410
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pappatm1Lex/Pappatm1Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:5523414
cn2
 		Pappatm1Lex/Pappatm1Lex
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129S5/SvEvBrd * C57BL/6 * CBA MGI:5523415


Genotype
MGI:5523414
hm1
Allelic
Composition		 Pappatm1Lex/Pappatm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pappatm1Lex mutation (1 available); any Pappa mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:201775 )
• mice exhibit no obvious abnormal phenotype




Genotype
MGI:5523415
cn2
Allelic
Composition		 Pappatm1Lex/Pappatm1Lex
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pappatm1Lex mutation (1 available); any Pappa mutation (72 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal vascular wound healing ( J:201775 )
• reduced neointima formation following carotid ligation in tamoxifen-treated mice
• however, media area is normal

homeostasis/metabolism
abnormal vascular wound healing ( J:201775 )
• reduced neointima formation following carotid ligation in tamoxifen-treated mice
• however, media area is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory