Phenotypes associated with this allele

• Allele Symbol: Exo1^tm3.1Wed
• Allele Name: targeted mutation 3.1, Winfried Edelmann
• Allele ID: MGI:5523450
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Exo1^tm3.1Wed/Exo1^tm3.1Wed	involves: 129 * C57BL/6	MGI:5523486
cx2	Exo1^tm3.1Wed/Exo1^tm3.1Wed Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * C57BL/6	MGI:5523487

Genotype
MGI:5523486

hm1

• Allelic Composition: Exo1^tm3.1Wed/Exo1^tm3.1Wed
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:198719 )

reproductive system

reproductive system phenotype ( J:198719 )

N • mice exhibit normal reproduction and meiosis

neoplasm

increased tumor incidence ( J:198719 )

• without an increase in microsatellite instability

increased adenoma incidence ( J:198719 )

• more so than in Exo1^tm2Wed homozygotes

increased lymphoma incidence ( J:198719 )

increased sarcoma incidence ( J:198719 )

• more so than in Exo1^tm2Wed homozygotes

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:198719 )

N • mice exhibit normal mutation frequency

abnormal double-strand DNA break repair ( J:198719 )

• mouse embryonic fibroblasts exhibit impaired double strand break repair through DNA end resection compared with wild-type cells

immune system

immune system phenotype ( J:198719 )

N • mice exhibit normal somatic hypermutation frequency and class switch recombination

cellular

abnormal double-strand DNA break repair ( J:198719 )

• mouse embryonic fibroblasts exhibit impaired double strand break repair through DNA end resection compared with wild-type cells

Genotype
MGI:5523487

cx2

• Allelic Composition: Exo1^tm3.1Wed/Exo1^tm3.1Wed; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * C57BL/6

mortality/aging

premature death ( J:198719 )

• survival is similar to in Trp53^tm1Tyj homozygotes

neoplasm

increased lymphoma incidence ( J:198719 )

• but less than in Trp53^tm1Tyj homozygotes

increased sarcoma incidence ( J:198719 )

• compared with Trp53^tm1Tyj homozygotes

cellular

abnormal chromosome stability ( J:198719 )

• mice exhibit the same amount of segmental chromosomal instability as in Trp53^tm1Tyj homozygotes