Analysis Tools
mortality/aging
reproductive system
 N |
• female mice exhibit normal fertility
|
 |
• very few spermatogenic cells progress through meiosis II
|
|
|
• very few spermatogenic cells progress through meiosis II
• abnormal metaphase configurations with abnormal spindle structures
|
small testis
(
J:198719
)
|
|
|
neoplasm
|
• less so than in Exo1tm3.1Wed homozygotes
|
|
• in most mice without an increase in microsatellite instability
|
|
• less so than in Exo1tm3.1Wed homozygotes
|
immune system
|
• mice treated with LPS or LPS and IL4 fail to exhibit efficient class switch recombination from IgM to IgG3 or IgG1 compared with wild-type mice
|
|
• splenic B cells from mice immunized with NP-CGG exhibit a decrease in the frequency of mutations at the A:T base pairs in Polh hotspots and a bias towards transition mutations at G:C base pairs compared with wild-type B cells
• however, the overall frequency of mutation is normal
|
cellular
|
|
• very few spermatogenic cells progress through meiosis II
|
|
|
• very few spermatogenic cells progress through meiosis II
• abnormal metaphase configurations with abnormal spindle structures
|
|
• mouse embryonic fibroblasts exhibit impaired double strand break repair through DNA end resection compared with wild-type cells
|
|
• increased mutation frequencies and an increase in transversions
|
homeostasis/metabolism
|
• mouse embryonic fibroblasts exhibit impaired double strand break repair through DNA end resection compared with wild-type cells
|
|
• increased mutation frequencies and an increase in transversions
|
endocrine/exocrine glands
small testis
(
J:198719
)
|
|
|
hematopoietic system
|
• mice treated with LPS or LPS and IL4 fail to exhibit efficient class switch recombination from IgM to IgG3 or IgG1 compared with wild-type mice
|
|
• splenic B cells from mice immunized with NP-CGG exhibit a decrease in the frequency of mutations at the A:T base pairs in Polh hotspots and a bias towards transition mutations at G:C base pairs compared with wild-type B cells
• however, the overall frequency of mutation is normal
|
