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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Notch1tm6.1Rko
targeted mutation 6.1, Raphael Kopan
MGI:5523515
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Notch1tm6.1Rko/Notch1+
Notch2tm3Grid/Notch2tm3Grid
Tg(Pax3-cre)1Joe/0 		involves: 129S1/Sv * C57BL/6 * SJL MGI:5523681
cn2
 		Notch1tm6.1Rko/Notch1tm6.1Rko
Notch2tm3Grid/Notch2tm3Grid
Tg(Pax3-cre)1Joe/0 		involves: 129S1/Sv * C57BL/6 * SJL MGI:5523682


Genotype
MGI:5523681
cn1
Allelic
Composition		 Notch1tm6.1Rko/Notch1+
Notch2tm3Grid/Notch2tm3Grid
Tg(Pax3-cre)1Joe/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1tm6.1Rko mutation (0 available); any Notch1 mutation (117 available)
Notch2tm3Grid mutation (2 available); any Notch2 mutation (99 available)
Tg(Pax3-cre)1Joe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal hypoplasia ( J:198632 )
• newborns have hypoplastic kidneys without functional nephrons; one copy of the N2ICD expressed from the Notch1 locus cannot rescue nephrons




Genotype
MGI:5523682
cn2
Allelic
Composition		 Notch1tm6.1Rko/Notch1tm6.1Rko
Notch2tm3Grid/Notch2tm3Grid
Tg(Pax3-cre)1Joe/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1tm6.1Rko mutation (0 available); any Notch1 mutation (117 available)
Notch2tm3Grid mutation (2 available); any Notch2 mutation (99 available)
Tg(Pax3-cre)1Joe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:198632 )
• pups die within 24 hours of birth

renal/urinary system
renal hypoplasia ( J:198632 )
• newborns have hypoplastic kidneys without functional nephrons; two copies of the Notch1 intracellular domain (N1ICD) expressed from the Notch2 locus cannot rescue nephrons




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory