Phenotypes associated with this allele

• Allele Symbol: Cers6^tm1.1Kwi
• Allele Name: targeted mutation 1.1, Klaus Willecke
• Allele ID: MGI:5523623
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cers6^tm1.1Kwi/Cers6^tm1.1Kwi	involves: 129P2/OlaHsd * C57BL/6	MGI:5523653

Genotype
MGI:5523653

hm1

• Allelic Composition: Cers6^tm1.1Kwi/Cers6^tm1.1Kwi
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:201327 )

N • mice exhibit normal exploratory activity in a novel environment, one-trial object recognition and anxiety-like behavior in an elevated plus maze

abnormal habituation to a new environment ( J:201327 )

• impaired after both short and long retention intervals

limb grasping ( J:201327 )

impaired coordination ( J:201327 )

• on a horizontal wire

increased vertical activity ( J:201327 )

• in an open field

increased locomotor activity ( J:201327 )

• increased locomotion, running speed and duration of movement in an open field

nervous ( J:201327 )

• mice are more agitated and nervous in an open field compared with wild-type mice

nervous system

microgliosis ( J:201327 )

• slightly increased density of microglia in the hippocampus with signs of degeneration

abnormal hippocampus morphology ( J:201327 )

• slightly increased density of microglia in the hippocampus with signs of degeneration

homeostasis/metabolism

abnormal lipid homeostasis ( J:201327 )

• mice exhibit a change in the composition of neutral sphingolipids (ceramide, sphyingomyelin and hexosylceramide) compared with wild-type mice

• however, glycerophospholipids remain normal

immune system

microgliosis ( J:201327 )

• slightly increased density of microglia in the hippocampus with signs of degeneration

hematopoietic system

microgliosis ( J:201327 )

• slightly increased density of microglia in the hippocampus with signs of degeneration