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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mgat5btm1Nta
targeted mutation 1, Naoyuki Taniguchi
MGI:5523679
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mgat5btm1Nta/Mgat5btm1Nta Not Specified MGI:5523685


Genotype
MGI:5523685
hm1
Allelic
Composition		 Mgat5btm1Nta/Mgat5btm1Nta
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mgat5btm1Nta mutation (0 available); any Mgat5b mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
brain inflammation ( J:199165 )
• milder than in wild-type mice after cuprizone administration
astrocytosis ( J:199165 )
• milder than in wild-type mice after cuprizone administration due to impaired astrocyte activation
increased oligodendrocyte number ( J:199165 )
• enhanced differentiation after cuprizone administration
• however, proliferation is normal
demyelination ( J:199165 )
• milder than in wild-type mice after cuprizone administration due to enhanced remyelination

homeostasis/metabolism
decreased susceptibility to injury ( J:199165 )
• cuprizone-treated mice exhibit milder demyelination, enhanced remyelination, reduced astrocytosis, reduced brain inflammation and enhanced oligodendrocyte differentiation compared with wild-type mice

immune system
brain inflammation ( J:199165 )
• milder than in wild-type mice after cuprizone administration




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory