Phenotypes associated with this allele

• Allele Symbol: Hoxd12^m1Hsj
• Allele Name: mutation 1, Han-Sung Jung
• Allele ID: MGI:5523688
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxd12^m1Hsj/Hoxd12^m1Hsj	involves: BALB/cJ	MGI:5523698

Genotype
MGI:5523698

hm1

• Allelic Composition: Hoxd12^m1Hsj/Hoxd12^m1Hsj
• Genetic Background: involves: BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal digit morphology ( J:202217 )

• widely expanded digits

abnormal phalanx morphology ( J:202217 )

• all the first phalanges are shorter and thicker than in wild-type mice

• digit I and II of the metatarsal bone is shorter, thicker and curved compared to in wild-type mice

• the proximal phalanx of digit II is thinner than in wild-type mice

• the middle phalanx of digit II is bent proximally

• the space between digits IV and V is larger than in wild-type mice

• however, the digital phalanx (tip) is normal

brachyphalangia ( J:202217 )

• on digit V, especially for the metacarpal bone and medial phalanx

• more significant in the fore limbs

brachydactyly ( J:202217 )

• macrodactyly at birth without syndactyly or polydactyly

• digit 1 is shorter than in wild-type mice

• however, digit IV on the forelimb is normal

clinodactyly ( J:202217 )

• digits I, II and V are curved (proximally)

oligodactyly ( J:202217 )

• tip of digit I is missing

abnormal forelimb morphology ( J:202217 )

• wider interosseous space of the fore limb

abnormal radius morphology ( J:202217 )

• small, misshapen and thin

• however, total length is normal

abnormal ulna morphology ( J:202217 )

• small, misshapen and thin

• however, total length is normal

abnormal hindlimb morphology ( J:202217 )

• short hind limbs

• narrower interosseous space of the hind limb

abnormal fibula morphology ( J:202217 )

abnormal tibia morphology ( J:202217 )

short metatarsal bones ( J:202217 )

• of digit I and not connected properly to the end of the metatarsal bone

short limbs ( J:202217 )

• at birth

short hindlimb ( J:202217 )

skeleton

abnormal phalanx morphology ( J:202217 )

• all the first phalanges are shorter and thicker than in wild-type mice

• digit I and II of the metatarsal bone is shorter, thicker and curved compared to in wild-type mice

• the proximal phalanx of digit II is thinner than in wild-type mice

• the middle phalanx of digit II is bent proximally

• the space between digits IV and V is larger than in wild-type mice

• however, the digital phalanx (tip) is normal

brachyphalangia ( J:202217 )

• on digit V, especially for the metacarpal bone and medial phalanx

• more significant in the fore limbs

abnormal radius morphology ( J:202217 )

• small, misshapen and thin

• however, total length is normal

abnormal ulna morphology ( J:202217 )

• small, misshapen and thin

• however, total length is normal

abnormal fibula morphology ( J:202217 )

abnormal tibia morphology ( J:202217 )

short metatarsal bones ( J:202217 )

• of digit I and not connected properly to the end of the metatarsal bone

abnormal joint morphology ( J:202217 )

• thicker joints