All Phenotypes Mybpc3<tm2.1Rmos> MGI Mouse

cardiovascular system phenotype ( J:202199 )

N	• gross cardiac morphology is normal 8 weeks after tamoxifen treatment

increased myocardial fiber size ( J:202199 )

• at 20 weeks in tamoxifen-treated mice

myocardial fiber disarray ( J:202199 )

• myocyte disarray in tamoxifen-treated mice 12 weeks after transaortic constriction

abnormal heart left ventricle morphology ( J:202199 )

• increased posterior wall thickness in diastole after 20 weeks of tamoxifen treatment

• increased left ventricle internal dimension in tamoxifen-treated mice after transaortic constriction

• however, internal dimension is normal after 20 weeks of tamoxifen treatment

cardiac fibrosis ( J:202199 )

• in tamoxifen-treated mice 12 weeks after transaortic constriction

cardiac interstitial fibrosis ( J:202199 )

• highly variable focal and diffuse 20 weeks after tamoxifen treatment

decreased heart ventricle muscle contractility ( J:202199 )

• decreased ejection fraction and isovolumic relaxation time in tamoxifen-treated mice

• reduced fractional shortening in tamoxifen-treated mice after transaortic constriction

• however, tamoxifen-treated mice exhibit normal left ventricle posterior wall thickness and left ventricle internal diameter

increased response of heart to induced stress ( J:202199 )

• following transaortic constriction, tamoxifen-treated mice exhibit increased left ventricle internal dimension and reduced fractional shortening compared with control mice