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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tet1tm1Gxu
targeted mutation 1, Guo-Liang Xu
MGI:5523868
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tet1tm1Gxu/Tet1tm1Gxu involves: 129 * C57BL/6J MGI:5523876
cn2
 		Tet1tm1Gxu/Tet1tm1.1Gxu
Tg(Nes-cre/ERT2)KEisc/0 		involves: 129 * C57BL/6J MGI:5523877


Genotype
MGI:5523876
cn1
Allelic
Composition		 Tet1tm1Gxu/Tet1tm1Gxu
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet1tm1Gxu mutation (0 available); any Tet1 mutation (143 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuronal precursor proliferation ( J:201001 )
• adult neural progenitor cells transfected with a cre-expressing adenovirus exhibit reduced neurosphere growth in culture compared with control cells

cellular
abnormal neuronal precursor proliferation ( J:201001 )
• adult neural progenitor cells transfected with a cre-expressing adenovirus exhibit reduced neurosphere growth in culture compared with control cells




Genotype
MGI:5523877
cn2
Allelic
Composition		 Tet1tm1Gxu/Tet1tm1.1Gxu
Tg(Nes-cre/ERT2)KEisc/0
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet1tm1.1Gxu mutation (0 available); any Tet1 mutation (143 available)
Tet1tm1Gxu mutation (0 available); any Tet1 mutation (143 available)
Tg(Nes-cre/ERT2)KEisc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:201001 )
• mice treated with tamoxifen at 2 months of age exhibit impaired adult neurogenesis compared with control mice
abnormal neuronal precursor proliferation ( J:201001 )
• mice treated with tamoxifen at 2 months of age exhibit decreased proliferation of intermediate progenitor cells in the dentate gyrus compared with control mice

cellular
abnormal neuron differentiation ( J:201001 )
• mice treated with tamoxifen at 2 months of age exhibit impaired adult neurogenesis compared with control mice
abnormal neuronal precursor proliferation ( J:201001 )
• mice treated with tamoxifen at 2 months of age exhibit decreased proliferation of intermediate progenitor cells in the dentate gyrus compared with control mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory