All Phenotypes Tet1<tm1.1Gxu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tet1^tm1.1Gxu/Tet1^tm1.1Gxu	involves: 129 * 129P2/OlaHsd * C57BL/6J	MGI:7662867
hm2	Tet1^tm1.1Gxu/Tet1^tm1.1Gxu	involves: 129 * C57BL/6J	MGI:5523878
cn3	Tet1^tm1.1Gxu/Tet1^tm1.1Gxu Tg(Nes-EGFP)33Enik/0	involves: 129 * BALB/cBy * C57BL/6 * C57BL/6J	MGI:5523879
cn4	Tet1^tm1Gxu/Tet1^tm1.1Gxu Tg(Nes-cre/ERT2)KEisc/0	involves: 129 * C57BL/6J	MGI:5523877

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal iron homeostasis ( J:315675 )

• mice fed a high-iron diet (HID) to induce systemic iron overload have disrupted iron metabolism, with increased serum iron levels and increased transferrin saturation compared to HID-fed controls

• however, when fed either a standard-iron diet (SID) or low-iron diet (LID), mice maintain normal serum iron and tissue non-heme iron levels

abnormal iron level ( J:315675 )

• HID-fed mice develop an accumulation of nonheme iron in the liver, lungs, and pancreas

• mice injected with iron dextran to cause iron overload mice show increased levels of nonheme iron in the liver, lungs, and pancreas

decreased intestinal iron level ( J:315675 )

• HID-fed mice show decreased iron in the duodenum

increased pancreas iron level ( J:315675 )

• HID-fed mice develop an accumulation of nonheme iron in the pancreas

• iron dextran-injected mice show increased levels of nonheme iron in the pancreas

decreased spleen iron level ( J:315675 )

• HID-fed mice show decreased nonheme iron in the spleen

• mice injected with iron dextran show lower levels of splenic nonheme iron compared with controls

increased circulating iron level ( J:315675 )

• HID-fed mice show increased serum iron levels

increased liver iron level ( J:315675 )

• HID-fed mice develop an accumulation of nonheme iron in the liver

• HID-fed mice show increased iron clustered in the liver periportal

• iron dextran-injected mice show increased levels of nonheme iron in the liver

digestive/alimentary system

decreased intestinal iron level ( J:315675 )

• HID-fed mice show decreased iron in the duodenum

endocrine/exocrine glands

increased pancreas iron level ( J:315675 )

• HID-fed mice develop an accumulation of nonheme iron in the pancreas

• iron dextran-injected mice show increased levels of nonheme iron in the pancreas

hematopoietic system

decreased spleen iron level ( J:315675 )

• HID-fed mice show decreased nonheme iron in the spleen

• mice injected with iron dextran show lower levels of splenic nonheme iron compared with controls

immune system

decreased spleen iron level ( J:315675 )

• HID-fed mice show decreased nonheme iron in the spleen

• mice injected with iron dextran show lower levels of splenic nonheme iron compared with controls

liver/biliary system

increased liver iron level ( J:315675 )

• HID-fed mice develop an accumulation of nonheme iron in the liver

• HID-fed mice show increased iron clustered in the liver periportal

• iron dextran-injected mice show increased levels of nonheme iron in the liver

Allelic Composition	Tet1^tm1.1Gxu/Tet1^tm1.1Gxu
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet1^tm1.1Gxu mutation (0 available); any Tet1 mutation (143 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired spatial learning ( J:201001 )

• in a 5-day acquisition trials in a Morris water maze, mice exhibit delayed learning based on escape latency and swim path compared with wild-type mice

• impaired short term memory retention 24 hours after a 5-day training in a Morris water maze

• however, long term memory after 3 weeks is normal

abnormal temporal memory ( J:201001 )

• impaired short term memory retention 24 hours after a 5-day training in a Morris water maze

• however, long term memory after 3 weeks is normal

nervous system

nervous system phenotype ( J:201001 )

N	• adult mice exhibit normal brain morphology

Allelic Composition	Tet1^tm1.1Gxu/Tet1^tm1.1Gxu Tg(Nes-EGFP)33Enik/0
Genetic Background	involves: 129 * BALB/cBy * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet1^tm1.1Gxu mutation (0 available); any Tet1 mutation (143 available)
Tg(Nes-EGFP)33Enik mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuronal precursor proliferation ( J:201001 )

• mice exhibit reduced adult subgranular zone neural progenitor pools compared with wild-type mice

• dentate gyrus primary neurospheres exhibit reduced self-renewal compared with wild-type cells

• however, differentiation potential is normal and galanin supplementation partially rescues proliferation

cellular

abnormal neuronal precursor proliferation ( J:201001 )

• mice exhibit reduced adult subgranular zone neural progenitor pools compared with wild-type mice

• dentate gyrus primary neurospheres exhibit reduced self-renewal compared with wild-type cells

• however, differentiation potential is normal and galanin supplementation partially rescues proliferation

abnormal DNA methylation ( J:201001 )

• neuronal progenitor cells exhibit hypermethylation compared with wild-type cells

Allelic Composition	Tet1^tm1Gxu/Tet1^tm1.1Gxu Tg(Nes-cre/ERT2)KEisc/0
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet1^tm1.1Gxu mutation (0 available); any Tet1 mutation (143 available)
Tet1^tm1Gxu mutation (0 available); any Tet1 mutation (143 available)
Tg(Nes-cre/ERT2)KEisc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:201001 )

• mice treated with tamoxifen at 2 months of age exhibit impaired adult neurogenesis compared with control mice

abnormal neuronal precursor proliferation ( J:201001 )

• mice treated with tamoxifen at 2 months of age exhibit decreased proliferation of intermediate progenitor cells in the dentate gyrus compared with control mice

cellular

abnormal neuron differentiation ( J:201001 )

• mice treated with tamoxifen at 2 months of age exhibit impaired adult neurogenesis compared with control mice

abnormal neuronal precursor proliferation ( J:201001 )

• mice treated with tamoxifen at 2 months of age exhibit decreased proliferation of intermediate progenitor cells in the dentate gyrus compared with control mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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